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Amyloid precursor protein

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[3nyj]], [[3nyl]], [[3umh]], [[3umi]], [[3umk]] – hAPP E2 domain – human<BR />
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*APP
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[[3ktm]] – hAPP residues 18-190<BR />
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-
[[1ze7]], [[2bp4]] – hAPP zinc-binding domain – NMR<BR />
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[[2fjz]], [[2fma]] - hAPP residues 133-189<BR />
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[[1owt]] - hAPP residues 133-189 - NMR<BR />
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[[1rw6]] - hAPP residues 346-551<BR />
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[[1tkn]] - hAPP residues 460-569 - NMR<BR />
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-
[[1qyt]], [[1qwp]], [[1qxc]] - hAPP residues 25-35 – NMR<BR />
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[[1mwp]] - hAPP heparin-binding domain<br />
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===hAPP β-peptide===
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**[[3nyj]], [[3nyl]], [[3umh]], [[3umi]], [[3umk]] – hAPP E2 domain – human<BR />
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**[[3ktm]] – hAPP residues 18-190<BR />
 +
**[[1ze7]], [[2bp4]] – hAPP zinc-binding domain – NMR<BR />
 +
**[[2fjz]], [[2fma]] - hAPP residues 133-189<BR />
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**[[1owt]] - hAPP residues 133-189 - NMR<BR />
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**[[1rw6]] - hAPP residues 346-551<BR />
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**[[1tkn]] - hAPP residues 460-569 - NMR<BR />
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**[[1qyt]], [[1qwp]], [[1qxc]] - hAPP residues 25-35 – NMR<BR />
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**[[1mwp]] - hAPP heparin-binding domain<br />
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[[1z0q]], [[2beg]] – hAPP β-peptide residues 1-42 – NMR<br />
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*hAPP β-peptide
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[[1amb]], [[1amc]] – hAPP β-peptide residues 1-28 – NMR<br />
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[[1qcm]], [[1qwp]], [[1qxc]], [[1qyt]] – hAPP β-peptide residues 25-35 – NMR<br />
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[[1ba4]], [[1ba6]], [[2lnq]] – hAPP β-peptide residues 1-40 – NMR<br />
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[[1bjb]], [[1bjc]] – hAPP β-peptide residues 1-28 (mutant) – NMR<br />
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[[1nmj]] – APP β-peptide residues 1-28 – rat – NMR<br />
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[[3bae]] – hAPP β-peptide residues 1-28 + antibody<br />
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[[3bkj]] – hAPP β-peptide residues 1-16 + antibody<br />
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[[2roz]] – hAPP β-peptide residues 1-32 + amyloid β A4 precursor protein - NMR<br />
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-
[[2wk3]] – hAPP β-peptide residues 1-42 + insulin-degrading enzyme<br />
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===Amyloid precursor protein binary complex===
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**[[1z0q]], [[2beg]] – hAPP β-peptide residues 1-42 – NMR<br />
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**[[1amb]], [[1amc]] – hAPP β-peptide residues 1-28 – NMR<br />
 +
**[[1qcm]], [[1qwp]], [[1qxc]], [[1qyt]] – hAPP β-peptide residues 25-35 – NMR<br />
 +
**[[1ba4]], [[1ba6]], [[2lnq]] – hAPP β-peptide residues 1-40 – NMR<br />
 +
**[[1bjb]], [[1bjc]] – hAPP β-peptide residues 1-28 (mutant) – NMR<br />
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**[[1nmj]] – APP β-peptide residues 1-28 – rat – NMR<br />
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**[[3bae]] – hAPP β-peptide residues 1-28 + antibody<br />
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**[[3bkj]] – hAPP β-peptide residues 1-16 + antibody<br />
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**[[2roz]] – hAPP β-peptide residues 1-32 + amyloid β A4 precursor protein - NMR<br />
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**[[2wk3]] – hAPP β-peptide residues 1-42 + insulin-degrading enzyme<br />
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[[1ze9]] - hAPP zinc-binding domain + Zn – NMR<BR />
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*Amyloid precursor protein binary complex
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[[2fk1]], [[2fk2]], [[2fk3]], [[2fkl]] - hAPP residues 133-189 + Cu<BR />
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[[3jti]], [[3gci]] – hAPP peptide + phospholipase A2<BR />
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[[3l81]] - hAPP peptide + AP-4 complex subunit μ-1<BR />
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[[3ifl]], [[3ifn]], [[3ifo]], [[3ifp]], [[2r0w]] - hAPP peptide + antibody<BR />
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[[2wk3]] - hAPP residues 1-42 + insulin degrading enzyme<BR />
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[[3dxc]] - hAPP residues 739-770 + Fe65-PTB2<BR />
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[[3dxd]], [[3dxe]] - hAPP residues 739-770 (mutant) + Fe65-PTB2<BR />
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[[2roz]] - hAPP peptide + Fe65 C terminal<BR />
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[[2otk]] - hAPP residues 672-711 + ZAB3 affibody dimer - NMR<BR />
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[[3l3t]] - hAPP residues 211-267 + mesotrypsin<br />
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[[3l33]] - hAPP residues 290-341 + trypsin-3 (mutant)
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 +
**[[1ze9]] - hAPP zinc-binding domain + Zn – NMR<BR />
 +
**[[2fk1]], [[2fk2]], [[2fk3]], [[2fkl]] - hAPP residues 133-189 + Cu<BR />
 +
**[[3jti]], [[3gci]] – hAPP peptide + phospholipase A2<BR />
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**[[3l81]] - hAPP peptide + AP-4 complex subunit μ-1<BR />
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**[[3ifl]], [[3ifn]], [[3ifo]], [[3ifp]], [[2r0w]] - hAPP peptide + antibody<BR />
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**[[2wk3]] - hAPP residues 1-42 + insulin degrading enzyme<BR />
 +
**[[3dxc]] - hAPP residues 739-770 + Fe65-PTB2<BR />
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**[[3dxd]], [[3dxe]] - hAPP residues 739-770 (mutant) + Fe65-PTB2<BR />
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**[[2roz]] - hAPP peptide + Fe65 C terminal<BR />
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**[[2otk]] - hAPP residues 672-711 + ZAB3 affibody dimer - NMR<BR />
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**[[3l3t]] - hAPP residues 211-267 + mesotrypsin<br />
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**[[3l33]] - hAPP residues 290-341 + trypsin-3 (mutant)
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:52, 17 November 2014

PDB ID 1mwp

Drag the structure with the mouse to rotate
Human amyloid precursor protein heparin-binding domain 1mwp
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Amyloid precursor protein (APP) is thought to regulate transcription. APP is cleaved by β-secretase and the resulting N terminal peptide which is ca. 40 amino acid long is called hAPP β-peptide. The aggregation of the hAPP β-peptide is the cause of Alzheimer’s Disease. For detailed discussion see


3D structures of amyloid precursor protein

Updated on 17-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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