Chaperonin

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Group I===
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*'''Group I'''
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''Large subunit''
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*''Large subunit''
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[[3m6c]] – MtGroEL1 apical domain – ''Mycobacterium tuberculosis''<BR />
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**[[3m6c]] – MtGroEL1 apical domain – ''Mycobacterium tuberculosis''<BR />
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[[1sjp]], [[3rtk]] – MtGroEL2 residues 42-539<BR />
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**[[1sjp]], [[3rtk]] – MtGroEL2 residues 42-539<BR />
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[[3fbh]], [[2eu1]], [[1j4z]], [[1kpo]], [[1oel]], [[1grl]], [[2yey]] – EcGroEL (mutant) - ''Escherichia coli''<BR />
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**[[3fbh]], [[2eu1]], [[1j4z]], [[1kpo]], [[1oel]], [[1grl]], [[2yey]] – EcGroEL (mutant) - ''Escherichia coli''<BR />
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[[3e76]], [[2nwc]], [[1xck]], [[1ss8]], [[4hel]] – EcGroEL<BR />
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**[[3e76]], [[2nwc]], [[1xck]], [[1ss8]], [[4hel]] – EcGroEL<BR />
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[[3c9v]], [[3cau]], [[2ynj]] – EcGroEL – Cryo EM<BR />
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**[[3c9v]], [[3cau]], [[2ynj]] – EcGroEL – Cryo EM<BR />
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[[2c7e]], [[1gr5]], [[4aaq]] - EcGroEL (mutant) – Cryo EM<BR />
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**[[2c7e]], [[1gr5]], [[4aaq]] - EcGroEL (mutant) – Cryo EM<BR />
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[[1dk7]] - EcGroEL apical domain<br />
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**[[1dk7]] - EcGroEL apical domain<br />
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[[1fy9]], [[1fya]], [[1kid]], [[1jon]], [[3vz6]], [[3vz7]], [[3vz8]] – EcGroEL apical domain (mutant) <BR />
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**[[1fy9]], [[1fya]], [[1kid]], [[1jon]], [[3vz6]], [[3vz7]], [[3vz8]] – EcGroEL apical domain (mutant) <BR />
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[[1srv]] – TtCPN60 apical domain - ''Thermus thermophilus''<BR />
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**[[1srv]] – TtCPN60 apical domain - ''Thermus thermophilus''<BR />
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[[3osx]] - CPN60 apical domain – ''Xenorhabdus nematophila''<br />
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**[[3osx]] - CPN60 apical domain – ''Xenorhabdus nematophila''<br />
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[[1iok]] – CPN60 – ''Paracoccus denitrificans''
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**[[1iok]] – CPN60 – ''Paracoccus denitrificans''
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''Large subunit binary complex''
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*''Large subunit binary complex''
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[[1kp8]] - EcGroEL (mutant) + ATP<BR />
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**[[1kp8]] - EcGroEL (mutant) + ATP<BR />
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[[4aar]], [[4aas]], [[4aau]], [[4ab2]], [[4ab3]] - EcGroEL (mutant) + ATP – Cryo EM<br />
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**[[4aar]], [[4aas]], [[4aau]], [[4ab2]], [[4ab3]] - EcGroEL (mutant) + ATP – Cryo EM<br />
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[[1sx3]] - EcGroEL + ATP<BR />
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**[[1sx3]] - EcGroEL + ATP<BR />
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[[1sx4]] - EcGroEL + ADP<BR />
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**[[1sx4]] - EcGroEL + ADP<BR />
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[[4ki8]] - EcGroEL (mutant) + ADP<br />
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**[[4ki8]] - EcGroEL (mutant) + ADP<br />
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[[1mnf]] – EcGroEL + polypeptide<BR />
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**[[1mnf]] – EcGroEL + polypeptide<BR />
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[[2cgt]] – EcGroEL + capsid assbly protein GP31 – EM<BR />
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**[[2cgt]] – EcGroEL + capsid assbly protein GP31 – EM<BR />
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[[1dkd]] - EcGroEL apical domain + polypeptide
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**[[1dkd]] - EcGroEL apical domain + polypeptide
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''Small subunit''
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*''Small subunit''
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[[3nx6]] – GroES residues 40-134 (mutant) – ''Xanthomonas oryzae''<BR />
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**[[3nx6]] – GroES residues 40-134 (mutant) – ''Xanthomonas oryzae''<BR />
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[[1wnr]] – TtCPN10 residues 1-94<BR />
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**[[1wnr]] – TtCPN10 residues 1-94<BR />
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[[1p3h]], [[1hx5]] – MtCPN10<BR />
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**[[1p3h]], [[1hx5]] – MtCPN10<BR />
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[[1p82]], [[1p83]] - MtCPN10 residues 1-25 - NMR<BR />
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**[[1p82]], [[1p83]] - MtCPN10 residues 1-25 - NMR<BR />
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[[1egs]] - GroES residues 19-27 - NMR
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**[[1egs]] - GroES residues 19-27 - NMR
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''Large + small subunit''
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*''Large + small subunit''
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[[1svt]], [[1pcq]] - EcGroEL + GroES<BR />
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**[[1svt]], [[1pcq]] - EcGroEL + GroES<BR />
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[[1pf9]], [[1aon]] - EcGroEL + GroES + ADP<BR />
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**[[1pf9]], [[1aon]] - EcGroEL + GroES + ADP<BR />
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[[2c7c]], [[2c7d]] - EcGroEL + GroES – Cryo EM<BR />
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**[[2c7c]], [[2c7d]] - EcGroEL + GroES – Cryo EM<BR />
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[[1gru]] - EcGroEL + GroES + ATP + ADP – Cryo EM<BR />
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**[[1gru]] - EcGroEL + GroES + ATP + ADP – Cryo EM<BR />
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[[3zpz]], [[3zq0]], [[3zq1]] - EcGroEL + GroES + ADP – Cryo EM<br />
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**[[3zpz]], [[3zq0]], [[3zq1]] - EcGroEL + GroES + ADP – Cryo EM<br />
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[[1we3]] – TtCPN60 + CPN10<BR />
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**[[1we3]] – TtCPN60 + CPN10<BR />
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[[1wf4]] - TtCPN60 + CPN10 + ADP
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**[[1wf4]] - TtCPN60 + CPN10 + ADP
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===Group II===
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*'''Group II'''
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[[3izh]], [[3izi]], [[3izj]], [[3izk]], [[3izl]], [[3izm]], [[3izn]], [[3los]], [[3iyf]], [[3j3x]] – MmCPN – ''Methanococcus maripaludis'' – EM<BR />
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**[[3izh]], [[3izi]], [[3izj]], [[3izk]], [[3izl]], [[3izm]], [[3izn]], [[3los]], [[3iyf]], [[3j3x]] – MmCPN – ''Methanococcus maripaludis'' – EM<BR />
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[[3kfb]], [[3kfe]], [[3kfk]] – MmCPN<BR />
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**[[3kfb]], [[3kfe]], [[3kfk]] – MmCPN<BR />
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[[3j02]], [[3j03]] – MmCPN (mutant) – Cryo EM<br />
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**[[3j02]], [[3j03]] – MmCPN (mutant) – Cryo EM<br />
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[[3ruq]] - MmCPN + ADP<br />
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**[[3ruq]] - MmCPN + ADP<br />
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[[3rus]] - MmCPN (mutant) + ADP<br />
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**[[3rus]] - MmCPN (mutant) + ADP<br />
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[[3ruw]] - MmCPN (mutant) + ADP-AlF3<br />
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**[[3ruw]] - MmCPN (mutant) + ADP-AlF3<br />
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[[3ruv]] - MmCPN (mutant) + ATP analog<br />
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**[[3ruv]] - MmCPN (mutant) + ATP analog<br />
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===CCT===
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*'''CCT'''
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[[2xsm]], [[4b2t]] – bCPN CCT – bovine<BR />
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**[[2xsm]], [[4b2t]] – bCPN CCT – bovine<BR />
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[[3p9d]], [[3p9e]], [[4d8q]], [[4d8r]], [[4aol]], [[4apk]] – CPN CCT - yeast<br />
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**[[3p9d]], [[3p9e]], [[4d8q]], [[4d8r]], [[4aol]], [[4apk]] – CPN CCT - yeast<br />
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[[3iyg]], [[4a0o]] - bCPN CCT – Cryo EM<BR />
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**[[3iyg]], [[4a0o]] - bCPN CCT – Cryo EM<BR />
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[[4a0v]] - bCPN CCT + AMPPNP – Cryo EM<br />
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**[[4a0v]] - bCPN CCT + AMPPNP – Cryo EM<br />
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[[4a0w]] - bCPN CCT + ADP + AlF3 – Cryo EM<br />
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**[[4a0w]] - bCPN CCT + ADP + AlF3 – Cryo EM<br />
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[[4a13]] - bCPN CCT + ADP – Cryo EM<br />
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**[[4a13]] - bCPN CCT + ADP – Cryo EM<br />
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[[3ktt]] - bCPN CCT β subunit – Cryo EM<BR />
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**[[3ktt]] - bCPN CCT β subunit – Cryo EM<BR />
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[[1gml]], [[1gn1]] - CPN CCT γ subunit apical domain – mouse
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**[[1gml]], [[1gn1]] - CPN CCT γ subunit apical domain – mouse
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===Hsp33===
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*'''Hsp33'''
See [[Heat Shock Proteins]]
See [[Heat Shock Proteins]]
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===Thermosome===
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*'''Thermosome'''
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[[1a6d]] - TaTherm α+β subunits – ''Thermoplasma acidophilum''<BR />
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**[[1a6d]] - TaTherm α+β subunits – ''Thermoplasma acidophilum''<BR />
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[[1a6e]] - TaTherm α+β subunits + ADP<BR />
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**[[1a6e]] - TaTherm α+β subunits + ADP<BR />
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[[1ass]], [[1asx]] - TaTherm α apical domain<BR />
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**[[1ass]], [[1asx]] - TaTherm α apical domain<BR />
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[[1e0r]] – TaTherm β apical domain<br />
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**[[1e0r]] – TaTherm β apical domain<br />
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[[3ko1]] – AtTherm α subunit– ''Acidianus tengchongensis''<br />
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**[[3ko1]] – AtTherm α subunit– ''Acidianus tengchongensis''<br />
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[[3j1b]], [[3j1c]], [[3j1e]] - AtTherm α subunit – Cryo EM <br />
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**[[3j1b]], [[3j1c]], [[3j1e]] - AtTherm α subunit – Cryo EM <br />
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[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br />
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**[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br />
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[[3aq1]] – Therm – ''Methanococcoides burtonii''<br />
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**[[3aq1]] – Therm – ''Methanococcoides burtonii''<br />
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[[1q2v]], [[1q3r]] – TkTherm α subunit (mutant) – Thermococcus KS-1<br />
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**[[1q2v]], [[1q3r]] – TkTherm α subunit (mutant) – Thermococcus KS-1<br />
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[[1q3q]] - TkTherm α subunit (mutant) + AMP-PNP<br />
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**[[1q3q]] - TkTherm α subunit (mutant) + AMP-PNP<br />
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[[1q3s]] - TkTherm α subunit (mutant) + ADP<br />
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**[[1q3s]] - TkTherm α subunit (mutant) + ADP<br />
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[[1lep]] – CPN-10 – ''Mycobacterium leprae''
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**[[1lep]] – CPN-10 – ''Mycobacterium leprae''
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:33, 20 November 2014

Crystal Structure of Chaperonin, 1pcq
Crystal Structure of Chaperonin, 1pcq

Template:STRUCTURE 1pcq













Chaperonins (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see Chaperonins in Wikipedia.

The most characterized CPN are in the GroEL/GroES complex from Escherichia coli and CPN60/CPN10 from Thermus thermophilus. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya.

3D Structures of Chaperonin

Updated on 20-November-2014

See Heat Shock Proteins

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