Deoxycytidine kinase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
- 
{{STRUCTURE_1p62| PDB=1p62 | SIZE=350| SCENE= |right|CAPTION= Human deoxycytidine kinase complex with ADP, chemotherapy agent gemcitabine (stick models) and Ca+2 ion (green) [[1p62]] }}
{{STRUCTURE_1p62| PDB=1p62 | SIZE=350| SCENE= |right|CAPTION= Human deoxycytidine kinase complex with ADP, chemotherapy agent gemcitabine (stick models) and Ca+2 ion (green) [[1p62]] }}
Line 7: Line 6:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
===dCK complex with chemotherapy agent===
+
*dCK complex with chemotherapy agent
-
 
+
-
[[1p5z]], [[1p62]], [[2a7q]] – hDCK + ADP + chemotherapy agent – human<br />
+
-
[[2no9]], [[2noa]], [[2no0]], [[2no6]], [[2zi9]] – hDCK (mutant) + ADP + chemotherapy agent <br />
+
-
[[2zia]] – hDCK (mutant) + UDP + chemotherapy agent <br />
+
-
===dCK complex with nucleoside===
+
**[[1p5z]], [[1p62]], [[2a7q]] – hDCK + ADP + chemotherapy agent – human<br />
 +
**[[2no9]], [[2noa]], [[2no0]], [[2no6]], [[2zi9]] – hDCK (mutant) + ADP + chemotherapy agent <br />
 +
**[[2zia]] – hDCK (mutant) + UDP + chemotherapy agent <br />
-
[[1p60]], [[1p61]], [[3kfx]] – hDCK + ADP + dC<br />
+
*dCK complex with nucleoside
-
[[2no1]], [[2no7]] – hDCK (mutant) + ADP + dC<br />
+
-
[[2zi3]], [[2zi4]] – hDCK (mutant) + ADP + dA<br />
+
-
[[3hp1]] – hDCK (mutant) + ADP + dT<br />
+
-
[[2zi5]], [[2zi6]] – hDCK (mutant) + UDP + dA<br />
+
-
[[2zi7]] – hDCK (mutant) + UDP + dG<br />
+
-
[[2a2z]], [[3qen]] – hDCK (mutant) + UDP + dC<br />
+
-
[[3qeo]] – hDCK (mutant) + UDP + dT<br />
+
-
[[2a30]] – hDCK (mutant) + dC<br />
+
-
===Other dCK complexes===
+
**[[1p60]], [[1p61]], [[3kfx]] – hDCK + ADP + dC<br />
 +
**[[2no1]], [[2no7]] – hDCK (mutant) + ADP + dC<br />
 +
**[[2zi3]], [[2zi4]] – hDCK (mutant) + ADP + dA<br />
 +
**[[3hp1]] – hDCK (mutant) + ADP + dT<br />
 +
**[[2zi5]], [[2zi6]] – hDCK (mutant) + UDP + dA<br />
 +
**[[2zi7]] – hDCK (mutant) + UDP + dG<br />
 +
**[[2a2z]], [[3qen]] – hDCK (mutant) + UDP + dC<br />
 +
**[[3qeo]] – hDCK (mutant) + UDP + dT<br />
 +
**[[2a30]] – hDCK (mutant) + dC<br />
-
[[2qrn]] – hDCK + UDP + CMP<br />
+
*Other dCK complexes
-
[[2qro]] – hDCK + UDP + AMP<br />
+
-
[[3ipx]] – hDCK + ADP + inbhibitor<br />
+
-
[[3ipy]] – hDCK + inbhibitor<br />
+
-
[[3qej]] – hDCK (mutant) + UDP <br />
+
-
[[4jlj]], [[4jlk]], [[4jlm]], [[4jln]], [[4l5b]] - hDCK (mutant) + UDP + inhibitor<br />
+
-
[[3mjr]] – hDCK + UDP + hydroxyethoxymethylguanine<br />
+
 +
**[[2qrn]] – hDCK + UDP + CMP<br />
 +
**[[2qro]] – hDCK + UDP + AMP<br />
 +
**[[3ipx]] – hDCK + ADP + inbhibitor<br />
 +
**[[3ipy]] – hDCK + inbhibitor<br />
 +
**[[3qej]] – hDCK (mutant) + UDP <br />
 +
**[[4jlj]], [[4jlk]], [[4jlm]], [[4jln]], [[4l5b]] - hDCK (mutant) + UDP + inhibitor<br />
 +
**[[3mjr]] – hDCK + UDP + hydroxyethoxymethylguanine<br />
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:22, 23 November 2014

Template:STRUCTURE 1p62

Deoxycytidine kinase (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA and nucleosides analogs which are used as antiviral and chemotherapeutic agents. Deficiency of DCK causes resistance to these agents.

3D Structures of deoxycytidine kinase

Updated on 23-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Deoxycytidine_kinase"
Personal tools