This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3kfy
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR== | |
| - | + | <StructureSection load='3kfy' size='340' side='right' caption='[[3kfy]], [[Resolution|resolution]] 2.08Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3kfy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KFY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=JZM:5-[(4-CHLOROPHENYL)SULFANYL]QUINAZOLINE-2,4-DIAMINE'>JZM</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dhf|1dhf]], [[3k45|3k45]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kfy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kfy RCSB], [http://www.ebi.ac.uk/pdbsum/3kfy PDBsum]</span></td></tr> |
| - | [[3kfy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFY OCA]. | + | </table> |
==See Also== | ==See Also== | ||
*[[Dihydrofolate reductase|Dihydrofolate reductase]] | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Carroll, M J | + | [[Category: Carroll, M J]] |
| - | [[Category: Collins, E J | + | [[Category: Collins, E J]] |
| - | [[Category: Gromova, A V | + | [[Category: Gromova, A V]] |
| - | [[Category: Lee, A L | + | [[Category: Lee, A L]] |
| - | [[Category: Miller, K R | + | [[Category: Miller, K R]] |
| - | [[Category: Singleton, S F | + | [[Category: Singleton, S F]] |
[[Category: Antibiotic resistance]] | [[Category: Antibiotic resistance]] | ||
[[Category: Dynamic]] | [[Category: Dynamic]] | ||
Revision as of 09:21, 9 December 2014
Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
| |||||||||||
Categories: Dihydrofolate reductase | Escherichia coli | Carroll, M J | Collins, E J | Gromova, A V | Lee, A L | Miller, K R | Singleton, S F | Antibiotic resistance | Dynamic | Methotrexate resistance | Nadp | One-carbon metabolism | Oxidoreductase | Small molecule inhibitor | Trimethoprim resistance
