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4j4b
From Proteopedia
(Difference between revisions)
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| - | + | ==PylD in complex with L-lysine-Ne-D-ornithine and NADH== | |
| - | + | <StructureSection load='4j4b' size='340' side='right' caption='[[4j4b]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4j4b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri_str._fusaro Methanosarcina barkeri str. fusaro]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4B FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0TF:N~6~-D-ORNITHYL-L-LYSINE'>0TF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t7v|3t7v]], [[4ffp|4ffp]], [[4j43|4j43]], [[4j49|4j49]], [[4j4h|4j4h]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mbar_A0835 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269797 Methanosarcina barkeri str. Fusaro])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4b RCSB], [http://www.ebi.ac.uk/pdbsum/4j4b PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The final step in the biosynthesis of the 22nd genetically encoded amino acid, pyrrolysine, is catalyzed by PylD, a structurally and mechanistically unique dehydrogenase. This catalyzed reaction includes an induced-fit mechanism achieved by major structural rearrangements of the N-terminal helix upon substrate binding. Different steps of the reaction trajectory are visualized by complex structures of PylD with substrate and product. | ||
| - | + | Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD).,Quitterer F, Beck P, Bacher A, Groll M Angew Chem Int Ed Engl. 2013 May 29. doi: 10.1002/anie.201301164. PMID:23720358<ref>PMID:23720358</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Methanosarcina barkeri str. fusaro]] | [[Category: Methanosarcina barkeri str. fusaro]] | ||
| - | [[Category: Bacher, A | + | [[Category: Bacher, A]] |
| - | [[Category: Beck, P | + | [[Category: Beck, P]] |
| - | [[Category: Groll, M | + | [[Category: Groll, M]] |
| - | [[Category: Quitterer, F | + | [[Category: Quitterer, F]] |
[[Category: 22nd amino acid]] | [[Category: 22nd amino acid]] | ||
[[Category: Biosynthesis]] | [[Category: Biosynthesis]] | ||
Revision as of 13:02, 21 December 2014
PylD in complex with L-lysine-Ne-D-ornithine and NADH
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