1k3v
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1k3v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Porcine_parvovirus Porcine parvovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K3V FirstGlance]. <br> | <table><tr><td colspan='2'>[[1k3v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Porcine_parvovirus Porcine parvovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K3V FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dpv|4dpv]], [[1fpv|1fpv]], [[1mvm|1mvm]], [[1dnv|1dnv]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dpv|4dpv]], [[1fpv|1fpv]], [[1mvm|1mvm]], [[1dnv|1dnv]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10796 Porcine parvovirus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10796 Porcine parvovirus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k3v RCSB], [http://www.ebi.ac.uk/pdbsum/1k3v PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k3v RCSB], [http://www.ebi.ac.uk/pdbsum/1k3v PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/COA1_PAVPN COA1_PAVPN]] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Porcine parvovirus]] | [[Category: Porcine parvovirus]] | ||
| - | [[Category: Hebert, B | + | [[Category: Hebert, B]] |
| - | [[Category: Parrish, C R | + | [[Category: Parrish, C R]] |
| - | [[Category: Rossmann, M G | + | [[Category: Rossmann, M G]] |
| - | [[Category: Simpson, A A | + | [[Category: Simpson, A A]] |
| - | [[Category: Sullivan, G M | + | [[Category: Sullivan, G M]] |
| - | [[Category: Tijssen, P | + | [[Category: Tijssen, P]] |
| - | [[Category: Zadori, Z | + | [[Category: Zadori, Z]] |
[[Category: Beta sheet]] | [[Category: Beta sheet]] | ||
[[Category: Capsid]] | [[Category: Capsid]] | ||
Revision as of 05:34, 25 December 2014
Porcine Parvovirus Capsid
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