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2blc
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2blc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BLC FirstGlance]. <br> | <table><tr><td colspan='2'>[[2blc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BLC FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CP7:6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE'>CP7</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CP7:6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE'>CP7</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bl9|2bl9]], [[2bla|2bla]], [[2blb|2blb]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bl9|2bl9]], [[2bla|2bla]], [[2blb|2blb]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2blc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2blc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2blc RCSB], [http://www.ebi.ac.uk/pdbsum/2blc PDBsum], [http://www.topsan.org/Proteins/RSGI/2blc TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2blc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2blc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2blc RCSB], [http://www.ebi.ac.uk/pdbsum/2blc PDBsum], [http://www.topsan.org/Proteins/RSGI/2blc TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Plasmodium vivax]] | [[Category: Plasmodium vivax]] | ||
| - | [[Category: Chitnumsub, P | + | [[Category: Chitnumsub, P]] |
| - | [[Category: Khongsuk, P | + | [[Category: Khongsuk, P]] |
| - | [[Category: Kongsaeree, P | + | [[Category: Kongsaeree, P]] |
| - | [[Category: Leartsakulpanich, U | + | [[Category: Leartsakulpanich, U]] |
| - | [[Category: Tarnchompoo, B | + | [[Category: Tarnchompoo, B]] |
| - | [[Category: Walkinshaw, M D | + | [[Category: Walkinshaw, M D]] |
| - | [[Category: Yuthavong, Y | + | [[Category: Yuthavong, Y]] |
| - | + | ||
[[Category: Double mutant]] | [[Category: Double mutant]] | ||
[[Category: Drug resistance]] | [[Category: Drug resistance]] | ||
[[Category: Malaria]] | [[Category: Malaria]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
| - | [[Category: Plasmodium vivax]] | ||
[[Category: Pyrimethamine]] | [[Category: Pyrimethamine]] | ||
[[Category: Thymidylate synthase]] | [[Category: Thymidylate synthase]] | ||
Revision as of 09:57, 8 January 2015
SP21 DOUBLE MUTANT P. VIVAX DIHYDROFOLATE REDUCTASE IN COMPLEX WITH DES-CHLOROPYRIMETHAMINE
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