Chaperonin
From Proteopedia
(Difference between revisions)
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**[[3c9v]], [[3cau]], [[2ynj]] – EcGroEL – Cryo EM<BR /> | **[[3c9v]], [[3cau]], [[2ynj]] – EcGroEL – Cryo EM<BR /> | ||
**[[2c7e]], [[1gr5]], [[4aaq]] - EcGroEL (mutant) – Cryo EM<BR /> | **[[2c7e]], [[1gr5]], [[4aaq]] - EcGroEL (mutant) – Cryo EM<BR /> | ||
| - | **[[1dk7]] - EcGroEL apical domain<br /> | + | **[[1dk7]], [[1la1]] - EcGroEL apical domain<br /> |
**[[1fy9]], [[1fya]], [[1kid]], [[1jon]], [[3vz6]], [[3vz7]], [[3vz8]] – EcGroEL apical domain (mutant) <BR /> | **[[1fy9]], [[1fya]], [[1kid]], [[1jon]], [[3vz6]], [[3vz7]], [[3vz8]] – EcGroEL apical domain (mutant) <BR /> | ||
**[[1srv]] – TtCPN60 apical domain - ''Thermus thermophilus''<BR /> | **[[1srv]] – TtCPN60 apical domain - ''Thermus thermophilus''<BR /> | ||
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**[[1svt]], [[1pcq]] - EcGroEL + GroES<BR /> | **[[1svt]], [[1pcq]] - EcGroEL + GroES<BR /> | ||
| - | **[[1pf9]], [[1aon]] - EcGroEL + GroES + ADP<BR /> | + | **[[1pf9]], [[1aon]], [[4pko]] - EcGroEL + GroES + ADP<BR /> |
| + | **[[3wvl]] - EcGroEL (mutant) + GroES + ATP<br /> | ||
**[[2c7c]], [[2c7d]] - EcGroEL + GroES – Cryo EM<BR /> | **[[2c7c]], [[2c7d]] - EcGroEL + GroES – Cryo EM<BR /> | ||
**[[1gru]] - EcGroEL + GroES + ATP + ADP – Cryo EM<BR /> | **[[1gru]] - EcGroEL + GroES + ATP + ADP – Cryo EM<BR /> | ||
**[[3zpz]], [[3zq0]], [[3zq1]] - EcGroEL + GroES + ADP – Cryo EM<br /> | **[[3zpz]], [[3zq0]], [[3zq1]] - EcGroEL + GroES + ADP – Cryo EM<br /> | ||
**[[1we3]] – TtCPN60 + CPN10<BR /> | **[[1we3]] – TtCPN60 + CPN10<BR /> | ||
| - | **[[1wf4]] - TtCPN60 + CPN10 + ADP | + | **[[1wf4]], [[4v4o]], [[4pkn]] - TtCPN60 + CPN10 + ADP |
*'''Group II''' | *'''Group II''' | ||
Revision as of 11:50, 15 March 2015
Chaperonins (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see Chaperonins in Wikipedia.
The most characterized CPN are in the GroEL/GroES complex from Escherichia coli and CPN60/CPN10 from Thermus thermophilus. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya. See also Chaperones.
3D Structures of Chaperonin
Updated on 15-March-2015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Eric Martz, Jaime Prilusky
