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1i02

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<table><tr><td colspan='2'>[[1i02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I02 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1i02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I02 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cb9|1cb9]], [[1cdt|1cdt]], [[2cdx|2cdx]], [[2crt|2crt]], [[1kxi|1kxi]], [[1tgx|1tgx]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cb9|1cb9]], [[1cdt|1cdt]], [[2cdx|2cdx]], [[2crt|2crt]], [[1kxi|1kxi]], [[1tgx|1tgx]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i02 RCSB], [http://www.ebi.ac.uk/pdbsum/1i02 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i02 OCA], [http://pdbe.org/1i02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i02 RCSB], [http://www.ebi.ac.uk/pdbsum/1i02 PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/3SA3_NAJAT 3SA3_NAJAT]] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells (PubMed:8182052). Interaction with sulfatides in the cell membrane induces pore formation and cell internalization. Cytotoxicity is due to pore formation, and to another mechanism independent of membrane-damaging activity. When internalized, it targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. It inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity (PubMed:16407244). It also binds with high affinity to heparin (PubMed:17685633).<ref>PMID:15922335</ref> <ref>PMID:16263708</ref> <ref>PMID:16407244</ref> <ref>PMID:17714752</ref> <ref>PMID:8182052</ref> <ref>PMID:8448165</ref> <ref>PMID:9245415</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1i02" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==

Revision as of 02:05, 11 September 2015

NMR STRUCTURE OF CTX A3 AT NEUTRAL PH (20 STRUCTURES)

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