Amino acid oxidase
From Proteopedia
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| - | {{STRUCTURE_2jb1| PDB= | + | {{STRUCTURE_2jb1| PDB=2jb1 | SIZE=400| SCENE= |right|CAPTION=Pit viper L-amino acid oxidase dimer containing FAD complex with aminobenzoate, [[2jb1]] }} |
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Revision as of 07:12, 1 November 2015
Contents |
Function
Amino acid oxidase catalyzes the oxidation of amino acids to the keto acid producing ammonia and hydrogen peroxide. These enzymes oxidize D-amino acids (DAO) and L-amino acids (LAO). The LAO oxidation products are 2-oxo acid, ammonia and hydrogen peroxide. LAO is widely found in snake venom. DAOs oxidize neutral and basic D-amino acids.
Relevance
Some DAOs are used in cancer therapy as inducers of oxidative stress and apoptosis. DAO and LAO use FAD as a cofactor.
Structural highlights
LAO structure contains 3 domains: FAD-binding, substrate-binding and helical domains. Active site residues include E209 and R90.
3D structures of amino acid oxidase
Updated on 01-November-2015
