Deoxycytidine kinase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The ability of <scene name='54/543346/Cv/ | + | The ability of <scene name='54/543346/Cv/3'>DCK to phosphorylate multiple nucleosides arises from the different conformations which the active site glutamic acid can assume</scene> (active site glutamates are in yellow).<ref>PMID:12808445</ref> |
</StructureSection> | </StructureSection> | ||
== 3D Structures of deoxycytidine kinase == | == 3D Structures of deoxycytidine kinase == | ||
Revision as of 14:11, 28 December 2015
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3D Structures of deoxycytidine kinase
Updated on 28-December-2015
References
- ↑ Hazra S, Ort S, Konrad M, Lavie A. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry. 2010 Aug 10;49(31):6784-90. PMID:20614893 doi:10.1021/bi100839e
- ↑ Sabini E, Ort S, Monnerjahn C, Konrad M, Lavie A. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nat Struct Biol. 2003 Jul;10(7):513-9. PMID:12808445 doi:http://dx.doi.org/10.1038/nsb942
