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| - | <includeonly></includeonly>==Human GPR40, also known as Free Fatty Acid Receptor 1 (FFAR1)== | + | <math></math><includeonly></includeonly>==Human GPR40, also known as Free Fatty Acid Receptor 1 (FFAR1)== |
<StructureSection load='Sele4phu.pdb' size='340' side='right' caption='hGPR40' scene='72/726431/General_protein/1'> | <StructureSection load='Sele4phu.pdb' size='340' side='right' caption='hGPR40' scene='72/726431/General_protein/1'> | ||
== Background == | == Background == | ||
| - | Human G-protein coupled receptor 40 (hGPR40) is a seven helical transmembrane domain receptor for long-chain free fatty acids that slimutates insulin secretion (Srivastava). This enzyme is primarily located in the pancreatic b-cells in the islets of Langerhans, and as such, it has become a target for potential Type II diabetes treatments (Kebede). Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration (Ma, 2016). GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43. | + | Human G-protein coupled receptor 40 (hGPR40) is a seven helical transmembrane domain receptor for long-chain free fatty acids that slimutates [[insulin]] secretion (Srivastava). This enzyme is primarily located in the pancreatic b-cells in the islets of Langerhans, and as such, it has become a target for potential Type II diabetes treatments (Kebede). Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration (Ma, 2016). GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43. |
== Structure == | == Structure == | ||
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=== ECL2 === | === ECL2 === | ||
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| + | [https://en.wikipedia.org/wiki/Beta_sheet] | ||
== Function == | == Function == | ||
Revision as of 12:06, 29 March 2016
<math></math>==Human GPR40, also known as Free Fatty Acid Receptor 1 (FFAR1)==
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