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== Background == | == Background == | ||
| - | Human G-protein coupled receptor 40 (hGPR40) is a seven helical transmembrane domain receptor for long-chain free fatty acids that slimutates [[insulin]] secretion (Srivastava). This enzyme is primarily located in the pancreatic b-cells in the islets of Langerhans, and as such, it has become a target for potential Type II diabetes treatments (Kebede). Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration (Ma, 2016). GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43. | ||
== Structure == | == Structure == | ||
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<scene name='72/721542/Tak_binding_site/3'>Tak-875 Binding Site</scene> | <scene name='72/721542/Tak_binding_site/3'>Tak-875 Binding Site</scene> | ||
[[Image:4phuBind2.png|200 px|right|thumb|Figure 2. Second proposed binding site of GPR40. By visual inspection, a second possible binding site was proposed between transmembrane helices 3, 4, and 5 on the intracellular side.]] | [[Image:4phuBind2.png|200 px|right|thumb|Figure 2. Second proposed binding site of GPR40. By visual inspection, a second possible binding site was proposed between transmembrane helices 3, 4, and 5 on the intracellular side.]] | ||
| - | [[Image:4phuBind3.png|200 px|right|thumb|Figure 3. Third proposed binding site of GPR40. By visual inspection, a third possible binding site was proposed between transmembrane helices 1, 2, and 7 on the extracellular side.]] | ||
[[Image:4phubind3.png|200 px|right|thumb|Figure 3. Third proposed binding site of GPR40. By visual inspection, a third possible binding site was proposed between transmembrane helices 1, 2, and 7 on the extracellular side.]] | [[Image:4phubind3.png|200 px|right|thumb|Figure 3. Third proposed binding site of GPR40. By visual inspection, a third possible binding site was proposed between transmembrane helices 1, 2, and 7 on the extracellular side.]] | ||
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=== ECL2 === | === ECL2 === | ||
| - | [https://en.wikipedia.org/wiki/Beta_sheet | + | [https://en.wikipedia.org/wiki/Beta_sheet beta sheet] |
== Function == | == Function == | ||
Current revision
<math></math>==Human GPR40, also known as Free Fatty Acid Receptor 1 (FFAR1)==
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