Nucleoside diphosphate kinase
From Proteopedia
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| - | + | <StructureSection load='1ucn' size='350' side='right' caption='Human nucleoside diphosphate kinase complex with ADP, phosphate and Ca+2 ion (green) (PDB entry [[1ucn]])' scene=''> | |
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== Function == | == Function == | ||
'''Nucleoside diphosphate kinase''' (NDK) catalyzes the exchange of phosphate between nucleoside triphosphate and nucleoside diphosphate. This reaction is a multi-step reaction which is used for the synthesis of nucleoside triphosphates other than ATP<ref>PMID:12972261</ref>. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerization. | '''Nucleoside diphosphate kinase''' (NDK) catalyzes the exchange of phosphate between nucleoside triphosphate and nucleoside diphosphate. This reaction is a multi-step reaction which is used for the synthesis of nucleoside triphosphates other than ATP<ref>PMID:12972261</ref>. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerization. | ||
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== Disease == | == Disease == | ||
NDKB deficiency causes diabetes-like vascular pathology<ref>PMID:25900369</ref>. | NDKB deficiency causes diabetes-like vascular pathology<ref>PMID:25900369</ref>. | ||
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| + | == Structural highlights == | ||
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| + | </StructureSection> | ||
==3D structures of nucleoside diphosphate kinase== | ==3D structures of nucleoside diphosphate kinase== | ||
Revision as of 08:19, 7 June 2016
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3D structures of nucleoside diphosphate kinase
Updated on 07-June-2016
References
- ↑ Chen Y, Gallois-Montbrun S, Schneider B, Veron M, Morera S, Deville-Bonne D, Janin J. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. J Mol Biol. 2003 Sep 26;332(4):915-26. PMID:12972261
- ↑ Qiu Y, Zhao D, Butenschon VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 2016 Feb;53(1):81-9. doi: 10.1007/s00592-015-0752-x. Epub 2015 Apr, 23. PMID:25900369 doi:http://dx.doi.org/10.1007/s00592-015-0752-x
