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Opioid receptor
From Proteopedia
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<StructureSection load='4djh' size='350' side='right' caption='Structure of κ-opioid receptor complex with opioid antagonist, citric acid, PEG and octadec-enoate derivative (PDB entry [[4djh]])' scene=''> | <StructureSection load='4djh' size='350' side='right' caption='Structure of κ-opioid receptor complex with opioid antagonist, citric acid, PEG and octadec-enoate derivative (PDB entry [[4djh]])' scene=''> | ||
| - | + | == Function == | |
'''Opioid receptor''' (OpR) is a G protein-coupled receptor with opioids as ligands<ref>PMID:22204322</ref>. OpR types are classified according to the ligands which bind to them.<br /> | '''Opioid receptor''' (OpR) is a G protein-coupled receptor with opioids as ligands<ref>PMID:22204322</ref>. OpR types are classified according to the ligands which bind to them.<br /> | ||
* The '''μ-opioid receptor''' binds morphine. For more details on μ-opioid receptor see [[Mu Opioid Receptor Bound to a Morphinan Antagonist]] and [[μ Opioid Receptors]].<br /> | * The '''μ-opioid receptor''' binds morphine. For more details on μ-opioid receptor see [[Mu Opioid Receptor Bound to a Morphinan Antagonist]] and [[μ Opioid Receptors]].<br /> | ||
* The '''κ-opioid receptor''' binds opium-type ligands. For details see [[Student Project 3 for UMass Chemistry 423 Spring 2015]].<br /> | * The '''κ-opioid receptor''' binds opium-type ligands. For details see [[Student Project 3 for UMass Chemistry 423 Spring 2015]].<br /> | ||
* The '''δ-opioid receptor''' binds enkephalins. For details see [[Delta opioid receptor]]. | * The '''δ-opioid receptor''' binds enkephalins. For details see [[Delta opioid receptor]]. | ||
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| + | == Relevance == | ||
| + | Nociceptin/orphanin FQ opioid receptor plays a role in the regulation of reward and motivation of substance abuse and is a target of drug abuse medication<ref>PMID:21050175</ref>. Its agonists are useful in treatment of pain, anxiety, edema and more and its antagonists are useful in pain management, depression, dementia and Parkinson disease<ref>PMID:17266536</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:25, 9 June 2016
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3D structures of opioid receptor
Updated on 09-June-2016
References
- ↑ Feng Y, He X, Yang Y, Chao D, Lazarus LH, Xia Y. Current research on opioid receptor function. Curr Drug Targets. 2012 Feb;13(2):230-46. PMID:22204322
- ↑ Zaveri NT. The nociceptin/orphanin FQ receptor (NOP) as a target for drug abuse medications. Curr Top Med Chem. 2011;11(9):1151-6. PMID:21050175
- ↑ Chiou LC, Liao YY, Fan PC, Kuo PH, Wang CH, Riemer C, Prinssen EP. Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications. Curr Drug Targets. 2007 Jan;8(1):117-35. PMID:17266536
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