Fatty acid synthase

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<StructureSection load='3tjm' size='450' side='right' scene='48/484817/Cv/1' caption='Human FAS thioesterase domain complex with fatty acid (PDB code [[3tjm]]) '>
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<StructureSection load='3tjm' size='350' side='right' scene='48/484817/Cv/1' caption='Human FAS thioesterase domain complex with fatty acid (PDB code [[3tjm]]) '>
== Function ==
== Function ==
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**[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br />
**[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br />
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**[[4bjd]], [[4bje]], [[4bjf]], [[4bjg]] – MtFAS I – Cryo-EM<br />
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**[[4v8w]] – MtFAS I – Cryo-EM<br />
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**[[3zen]], [[4b3y]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br />
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**[[4v8l]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br />
**[[1xkt]] – hFAS thioesterase domain – human<br />
**[[1xkt]] – hFAS thioesterase domain – human<br />
**[[2jfd]] – hFAS MAT domain<br />
**[[2jfd]] – hFAS MAT domain<br />
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**[[2uv8]], [[3hmj]] – yFAS α+β subunits - yeast<br />
**[[2uv8]], [[3hmj]] – yFAS α+β subunits - yeast<br />
**[[2pff]], [[2was]], [[2ml8]] – yFAS α subunit<br />
**[[2pff]], [[2was]], [[2ml8]] – yFAS α subunit<br />
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**[[2uv9]] – TlFAS α subunits – ''Thermomyces lanuginosus''<br />
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**[[4v58]] – TlFAS – ''Thermomyces lanuginosus''<br />
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**[[2uva]] – TlFAS β subunits<br />
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**[[2png]] – FAS ACP domain – rat<br />
**[[2png]] – FAS ACP domain – rat<br />
**[[1t8k]] – EcFAS ACP domain - ''Escherichia coli''<br />
**[[1t8k]] – EcFAS ACP domain - ''Escherichia coli''<br />
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**[[2jfk]] – hFAS + malonyl CoA<br />
**[[2jfk]] – hFAS + malonyl CoA<br />
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**[[2uvc]] – TlFAS β subunits + NADP<BR />
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**[[4v59]] – TlFAS + NADP<BR />
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**[[2uvb]] – TlFAS α subunits + NADP<BR />
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**[[2wat]] – yFAS α subunit + CoA<br />
**[[2wat]] – yFAS α subunit + CoA<br />
**[[2vz9]] – pFAS + NADP<BR />
**[[2vz9]] – pFAS + NADP<BR />

Revision as of 07:56, 17 November 2016

Human FAS thioesterase domain complex with fatty acid (PDB code 3tjm)

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3D structures of fatty acid synthase

Updated on 17-November-2016

References

  1. ↑ Smith S, Witkowski A, Joshi AK. Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res. 2003 Jul;42(4):289-317. PMID:12689621
  2. ↑ Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-{gamma}-linolenic acid. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15757-62. Epub 2011 Sep 9. PMID:21908709 doi:10.1073/pnas.1112334108

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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