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Proton Channels

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-The M2 protein of influenza A virus is a proton channel. Its function is essential to infection by the virus.
+<StructureSection load='' size='450' side='right' scene='Proton_Channels/Cartoon/2' caption='Linear interpolation morph from [[3bkd]] to model 1 of [[2rlf]]. '>
-In January, 2008, crystallographic and NMR structures were published side by side for the transmembrane domains of the M2 protein: [[3bkd]] and [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine.
+The M2 protein of influenza A virus is a proton channel. Its function is essential for productive infection by the virus.
-At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel.
+See [[:Category:Proton_channel]] for a list of all proton channel structures.
+In January, 2008, crystallographic and NMR structures were published side by side in ''Nature'' for the transmembrane domains of the M2 protein: [[3bkd]] to [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine. (Neither drug is shown in the morph at right.)
+<!-- THESE LINKS DO NOT WORK IN THE CAPTION; NEITHER DOES THE FORM [[3bkd]]
+caption='Linear interpolation morph from [http://proteopedia.org/wiki/index.php/3bkd 3bkd] to [http://proteopedia.org/wiki/index.php/2rlf 2rlf model 1] ' />
+-->
+At right is a [[Morphs|linear-interpolation morph]] between 3BKD and 2RLF, showing the proposed opening and closing of this channel. {{Button_Toggle_Animation2}}
+In addition to watching the animation as alpha-helical ribbons, it is useful to watch it <scene name='Proton_Channels/Spacefilled/1'>spacefilled</scene>. '''Be sure to rotate the molecule with your mouse to watch the animation from different perspectives!'''
+<scene name='Proton_Channels/Gating/1'>His37 and Trp41</scene> are believed to be crucial for pH-dependent gating.
+(The apparent collapse and re-expansion of their sidechains is an artifact due to the [[Morphs|linear interpolation method of morphing]].) Here are His and Trp <scene name='Proton_Channels/Gating/2'>spacefilled</scene>.
+To be explained in a later revision, along with new scenes:
+[http://www.molmovdb.org/cgi-bin/morph.cgi?ID=b505428-6008 Morph from Yale]
+{{Clear}}
+==3D structures of ion channels==
+[[Ion channels]]
+==Additional Resources==
+For additional information, see: [[Influenza]] <br />
+For additional information, see: [[Membrane Channels & Pumps]]
+<br />
+<br />

Current revision

spinqualitylabelsall models

Linear interpolation morph from 3bkd to model 1 of 2rlf.

Show:Asymmetric Unit Biological Assembly

Drag the structure with the mouse to rotate

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The M2 protein of influenza A virus is a proton channel. Its function is essential for productive infection by the virus.

See Category:Proton_channel for a list of all proton channel structures.

In January, 2008, crystallographic and NMR structures were published side by side in Nature for the transmembrane domains of the M2 protein: 3bkd to 2rlf. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine. (Neither drug is shown in the morph at right.)

At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel.

In addition to watching the animation as alpha-helical ribbons, it is useful to watch it . Be sure to rotate the molecule with your mouse to watch the animation from different perspectives!

are believed to be crucial for pH-dependent gating.

(The apparent collapse and re-expansion of their sidechains is an artifact due to the linear interpolation method of morphing.) Here are His and Trp .

To be explained in a later revision, along with new scenes:

Morph from Yale