Nucleoside diphosphate kinase

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Line 23: Line 23:
**[[1leo]], [[1ncl]], [[1hlw]], [[1hhq]], [[1pae]], [[4c6a]] - DdNDK (mutant) <BR />
**[[1leo]], [[1ncl]], [[1hlw]], [[1hhq]], [[1pae]], [[4c6a]] - DdNDK (mutant) <BR />
**[[2nck]] – MxNDK – ''Myxococcus xanthus''<BR />
**[[2nck]] – MxNDK – ''Myxococcus xanthus''<BR />
-
**[[1ndl]] – DmNDK – ''Drosophila melanogaster''<BR />
+
**[[1ndl]], [[3wx8]] – DmNDK – ''Drosophila melanogaster''<BR />
**[[1nsq]] - DmNDK with phosphohistidine intermediate<BR />
**[[1nsq]] - DmNDK with phosphohistidine intermediate<BR />
**[[1nsk]], [[1jxv]], [[3l7u]], [[4eno]] - hNDK A – human<BR />
**[[1nsk]], [[1jxv]], [[3l7u]], [[4eno]] - hNDK A – human<BR />
Line 47: Line 47:
**[[3r9l]] - NDK – ''Giardia lamblia''<BR />
**[[3r9l]] - NDK – ''Giardia lamblia''<BR />
**[[3ngr]], [[3ngs]] - LmNDK – ''Leishmania major''<BR />
**[[3ngr]], [[3ngs]] - LmNDK – ''Leishmania major''<BR />
 +
**[[5c7p]], [[5caa]], [[5cab]] - LmNDK (mutant)<br />
 +
**[[4kpc]] - NDK – ''Leishmania braziliensis''<br />
 +
**[[5go1]] - NDK – ''Leishmania amazonensis''<br />
**[[3prv]] - NDK – ''Trypanosoma cruzi''<BR />
**[[3prv]] - NDK – ''Trypanosoma cruzi''<BR />
**[[3q83]] - SaNDK – ''Staphylococcus aureus''<BR />
**[[3q83]] - SaNDK – ''Staphylococcus aureus''<BR />
Line 58: Line 61:
**[[3vvu]] - NDK – reconstructed bacterial ancestral<br />
**[[3vvu]] - NDK – reconstructed bacterial ancestral<br />
**[[4f36]] – TbNDK – ''Trypanosoma brucei''<br />
**[[4f36]] – TbNDK – ''Trypanosoma brucei''<br />
 +
**[[1vya]] – NDK – maize<br />
 +
**[[4s0m]], [[4w98]], [[4wbf]] – NDK – ''Acinetobacter baumannii''<br />
 +
**[[5iol]], [[5iom]] - SmNDK – ''Schisostoma mansoni''<br />
 +
**[[5u2i]] – NDK – ''Naegleria fowleri''<br />
 +
**[[5v6d]] – NDK – ''Neisseria gonnorrhoeae''<br />
*NDK complex with adenine derivative
*NDK complex with adenine derivative
Line 77: Line 85:
**[[4ek2]] - BtNDK + AMP derivative<br />
**[[4ek2]] - BtNDK + AMP derivative<br />
**[[4hr2]] - BtNDK + ADP<br />
**[[4hr2]] - BtNDK + ADP<br />
 +
**[[4uof]], [[4uoh]] - sNDK + ADP derivative – shrimp <br />
 +
**[[5kk8]] - SmNDK + ADP<br />
*NDK complex with thymidine derivative
*NDK complex with thymidine derivative
Line 97: Line 107:
**[[3q89]] - SaNDK + CDP<BR />
**[[3q89]] - SaNDK + CDP<BR />
**[[4fkx]] - TbNDK + CDP<br />
**[[4fkx]] - TbNDK + CDP<br />
 +
**[[4uog]] - sNDK + CDP derivative <br />
*NDK complex with guanine derivative
*NDK complex with guanine derivative
Line 110: Line 121:
**[[3fbe]], [[3dkd]], [[3ejm]] - ApNDK (mutant) + GDP<BR />
**[[3fbe]], [[3dkd]], [[3ejm]] - ApNDK (mutant) + GDP<BR />
**[[3emt]], [[3ena]] - ApNDK (mutant) + GDP derivative<br />
**[[3emt]], [[3ena]] - ApNDK (mutant) + GDP derivative<br />
-
**[[3q86]] - SaNDK + GTP
+
**[[3q86]] - SaNDK + GTP<br />
 +
[[4fky]] - TbNDK + GTP<br />
*NDK complex with uridine derivative
*NDK complex with uridine derivative
Line 124: Line 136:
*NDK complex with antiviral drug
*NDK complex with antiviral drug
-
**[[1mn9]], [[3fkb]] - DdNDK (mutant) + antiviral drug
+
**[[1mn9]], [[3fkb]] - DdNDK (mutant) + antiviral drug<br />
 +
**[[4cp5]] - DdNDK (mutant) + PMPAPP<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:57, 28 August 2017

Human nucleoside diphosphate kinase complex with ADP, phosphate, TRIS and Ca+2 ion (green) (PDB entry 1ucn)

Drag the structure with the mouse to rotate

3D structures of nucleoside diphosphate kinase

Updated on 28-August-2017

4fky - TbNDK + GTP

References

  1. Janin J, Dumas C, Morera S, Xu Y, Meyer P, Chiadmi M, Cherfils J. Three-dimensional structure of nucleoside diphosphate kinase. J Bioenerg Biomembr. 2000 Jun;32(3):215-25. PMID:11768305
  2. Qiu Y, Zhao D, Butenschon VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 2016 Feb;53(1):81-9. doi: 10.1007/s00592-015-0752-x. Epub 2015 Apr, 23. PMID:25900369 doi:http://dx.doi.org/10.1007/s00592-015-0752-x
  3. Chen Y, Gallois-Montbrun S, Schneider B, Veron M, Morera S, Deville-Bonne D, Janin J. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. J Mol Biol. 2003 Sep 26;332(4):915-26. PMID:12972261

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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