1v0z

From Proteopedia

(Difference between revisions)

Revision as of 07:57, 28 March 2018

Structure of Neuraminidase from English duck subtype N6

Structural highlights

1v0z is a 4 chain structure with sequence from 9infa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , , , ,
Related:	1a14, 1a4g, 1a4q, 1b9s, 1b9t, 1b9v, 1bji, 1e8t, 1e8u, 1e8v, 1euu, 1f8b, 1f8c, 1f8d, 1f8e, 1inf, 1ing, 1inh, 1inv, 1inw, 1inx, 1iny, 1ivb, 1ivc, 1ivd, 1ive, 1ivf, 1ivg, 1kit, 1l7f, 1l7g, 1l7h, 1mwe, 1nca, 1ncb, 1ncc, 1ncd, 1nma, 1nmb, 1nmc, 1nn2, 1nna, 1nnb, 1nnc, 1nsb, 1nsc, 1nsd, 1usr, 1usx, 1v2i, 1v3b, 1v3c, 1v3d, 1v3e, 1vcj, 1w1x, 1w20, 1w21, 1w8n, 1w8o, 1xoe, 1xog, 1z4v, 1z4w, 1z4x, 1z4y, 1z4z, 1z50, 2bat, 2qwa, 2qwb, 2qwc, 2qwd, 2qwe, 2qwf, 2qwg, 2qwh, 2qwi, 2qwj, 2qwk, 2sil, 2sim, 3nn9, 4nn9, 5nn9, 6nn9, 7nn9
Activity:	Exo-alpha-sialidase, with EC number 3.2.1.18
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NRAM_I56A2] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1v0z"

@@ Line 1: / Line 1: @@
-==STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE N6==
+==Structure of Neuraminidase from English duck subtype N6==
 <StructureSection load='1v0z' size='340' side='right' caption='[[1v0z]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
 == Structural highlights ==
@@ Line 6: / Line 7: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a14|1a14]], [[1a4g|1a4g]], [[1a4q|1a4q]], [[1b9s|1b9s]], [[1b9t|1b9t]], [[1b9v|1b9v]], [[1bji|1bji]], [[1e8t|1e8t]], [[1e8u|1e8u]], [[1e8v|1e8v]], [[1euu|1euu]], [[1f8b|1f8b]], [[1f8c|1f8c]], [[1f8d|1f8d]], [[1f8e|1f8e]], [[1inf|1inf]], [[1ing|1ing]], [[1inh|1inh]], [[1inv|1inv]], [[1inw|1inw]], [[1inx|1inx]], [[1iny|1iny]], [[1ivb|1ivb]], [[1ivc|1ivc]], [[1ivd|1ivd]], [[1ive|1ive]], [[1ivf|1ivf]], [[1ivg|1ivg]], [[1kit|1kit]], [[1l7f|1l7f]], [[1l7g|1l7g]], [[1l7h|1l7h]], [[1mwe|1mwe]], [[1nca|1nca]], [[1ncb|1ncb]], [[1ncc|1ncc]], [[1ncd|1ncd]], [[1nma|1nma]], [[1nmb|1nmb]], [[1nmc|1nmc]], [[1nn2|1nn2]], [[1nna|1nna]], [[1nnb|1nnb]], [[1nnc|1nnc]], [[1nsb|1nsb]], [[1nsc|1nsc]], [[1nsd|1nsd]], [[1usr|1usr]], [[1usx|1usx]], [[1v2i|1v2i]], [[1v3b|1v3b]], [[1v3c|1v3c]], [[1v3d|1v3d]], [[1v3e|1v3e]], [[1vcj|1vcj]], [[1w1x|1w1x]], [[1w20|1w20]], [[1w21|1w21]], [[1w8n|1w8n]], [[1w8o|1w8o]], [[1xoe|1xoe]], [[1xog|1xog]], [[1z4v|1z4v]], [[1z4w|1z4w]], [[1z4x|1z4x]], [[1z4y|1z4y]], [[1z4z|1z4z]], [[1z50|1z50]], [[2bat|2bat]], [[2qwa|2qwa]], [[2qwb|2qwb]], [[2qwc|2qwc]], [[2qwd|2qwd]], [[2qwe|2qwe]], [[2qwf|2qwf]], [[2qwg|2qwg]], [[2qwh|2qwh]], [[2qwi|2qwi]], [[2qwj|2qwj]], [[2qwk|2qwk]], [[2sil|2sil]], [[2sim|2sim]], [[3nn9|3nn9]], [[4nn9|4nn9]], [[5nn9|5nn9]], [[6nn9|6nn9]], [[7nn9|7nn9]]</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0z OCA], [http://pdbe.org/1v0z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v0z RCSB], [http://www.ebi.ac.uk/pdbsum/1v0z PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0z OCA], [http://pdbe.org/1v0z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v0z RCSB], [http://www.ebi.ac.uk/pdbsum/1v0z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v0z ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 14: / Line 15: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v0z_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v0z_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v0z ConSurf].
 <div style="clear:both"></div>

1v0z

From Proteopedia

Revision as of 07:57, 28 March 2018

Structure of Neuraminidase from English duck subtype N6

Structural highlights

Function

Evolutionary Conservation

See Also

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