Dipeptidyl peptidase
From Proteopedia
(Difference between revisions)
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**[[5ehh]] - hDPP-III (mutant) + endomorphin II<br /> | **[[5ehh]] - hDPP-III (mutant) + endomorphin II<br /> | ||
**[[3csk]] – DPP-III (mutant) – yeast<br /> | **[[3csk]] – DPP-III (mutant) – yeast<br /> | ||
| + | **[[5yfb]], [[5yfc]], [[5yfd]] – DPP-III – mushroom<br /> | ||
*DPP-IV (CD26) | *DPP-IV (CD26) | ||
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**[[3kwj]], [[3oc0]], [[3kwf]], [[3q8w]] – hDPP-IV extracellular domain +quinoline derivative<br /> | **[[3kwj]], [[3oc0]], [[3kwf]], [[3q8w]] – hDPP-IV extracellular domain +quinoline derivative<br /> | ||
**[[3g0b]], [[3g0d]], [[3g0g]], [[3nox]], [[3hab]], [[3hac]], [[3f8s]], [[3h0c]], [[3ccb]], [[3ccc]], [[2qjr]], [[2qky]], [[3d4l]], [[2jid]], [[3bjm]], [[2rip]], [[2ole]], [[2rgu]], [[2i78]], [[2oag]], [[2oqv]], [[2oqi]], [[2ogz]], [[2i03]], [[2g5p]], [[2g5t]], [[2g63]], [[2bub]], [[2ajl]], [[1wcy]], [[1rwq]], [[1tkr]], [[1n1m]], [[3eio]], [[3g0c]], [[3opm]], [[3sww]], [[3sx4]], [[3q0t]], [[4a5s]], [[3vjk]], [[3vjl]], [[3vjm]], [[3w2t]], [[4dsa]], [[4dsz]], [[4dtc]], [[4g1f]],[[3o95]], [[3o9v]], [[4j3j]], [[4jh0]], [[4lko]], [[4n8d]], [[4n8e]], [[4pnz]], [[4pv7]], [[3wqh]], [[5i7u]], [[5j3j]], [[5kby]], [[5t4b]], [[5t4e]], [[5t4f]], [[5t4h]] – hDPP-IV extracellular domain+inhibitor<br /> | **[[3g0b]], [[3g0d]], [[3g0g]], [[3nox]], [[3hab]], [[3hac]], [[3f8s]], [[3h0c]], [[3ccb]], [[3ccc]], [[2qjr]], [[2qky]], [[3d4l]], [[2jid]], [[3bjm]], [[2rip]], [[2ole]], [[2rgu]], [[2i78]], [[2oag]], [[2oqv]], [[2oqi]], [[2ogz]], [[2i03]], [[2g5p]], [[2g5t]], [[2g63]], [[2bub]], [[2ajl]], [[1wcy]], [[1rwq]], [[1tkr]], [[1n1m]], [[3eio]], [[3g0c]], [[3opm]], [[3sww]], [[3sx4]], [[3q0t]], [[4a5s]], [[3vjk]], [[3vjl]], [[3vjm]], [[3w2t]], [[4dsa]], [[4dsz]], [[4dtc]], [[4g1f]],[[3o95]], [[3o9v]], [[4j3j]], [[4jh0]], [[4lko]], [[4n8d]], [[4n8e]], [[4pnz]], [[4pv7]], [[3wqh]], [[5i7u]], [[5j3j]], [[5kby]], [[5t4b]], [[5t4e]], [[5t4f]], [[5t4h]] – hDPP-IV extracellular domain+inhibitor<br /> | ||
| + | **[[6b1e]], [[6b1o]] – hDPP-IV extracellular domain (mutant) +inhibitor<br /> | ||
**[[1r9n]], [[2bgr]], [[1nu8]] – hDPP-IV extracellular domain+polypeptide<br /> | **[[1r9n]], [[2bgr]], [[1nu8]] – hDPP-IV extracellular domain+polypeptide<br /> | ||
**[[1w1i]] – hDPP-IV extracellular domain+adenosine deaminase<br /> | **[[1w1i]] – hDPP-IV extracellular domain+adenosine deaminase<br /> | ||
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**[[2aj8]], [[2ajb]], [[2ajc]], [[2ajd]], [[2bua]], [[2buc]], [[1orw]], [[5lls]] – pDPP-IV extracellular domain+inhibitor - pig<br /> | **[[2aj8]], [[2ajb]], [[2ajc]], [[2ajd]], [[2bua]], [[2buc]], [[1orw]], [[5lls]] – pDPP-IV extracellular domain+inhibitor - pig<br /> | ||
**[[1orv]] - pDPP-IV extracellular domain<br /> | **[[1orv]] - pDPP-IV extracellular domain<br /> | ||
| - | **[[2ecf]] - DPP-IV – ''Stenotrophomonas maltophilia'' | + | **[[2ecf]] - DPP-IV – ''Stenotrophomonas maltophilia''<br /> |
| + | **[[5olj]] – PgDPP-IV – ''Porphyromonas gingivalis''<br /> | ||
*DPP-VI | *DPP-VI | ||
**[[3pvq]], [[4r0k]] – DPP-VI – ''Bacterioides thetaiotamicron'' | **[[3pvq]], [[4r0k]] – DPP-VI – ''Bacterioides thetaiotamicron'' | ||
| + | |||
| + | *DPP-VIII | ||
| + | |||
| + | **[[6eos]], [[6eoo]] – hDPP-VIII <br /> | ||
| + | **[[6eot]], [[6eop]] – hDPP-VIII + polypeptide<br /> | ||
| + | |||
| + | *DPP-IX | ||
| + | |||
| + | **[[6eoq]], [[6eor]] – hDPP-IX <br /> | ||
*DPP-X | *DPP-X | ||
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**[[4wjl]] – hDPP-X extracellular domain<br /> | **[[4wjl]] – hDPP-X extracellular domain<br /> | ||
| - | *DPP-XI or peptidase S46 | + | *DPP-XI or peptidase S46 or Asp/Glu-specific DPP |
| - | **[[4xzy]], [[4y01]], [[4y02]], [[4y04]] – | + | **[[4xzy]], [[4y01]], [[4y02]], [[4y04]] – PgDPP-XI <br /> |
| + | **[[5jxp]], [[5jxk]], [[5jwf]] – PeDPP-XI – ''Porphyromonas endodontalis''<br /> | ||
| + | **[[5jy0]], [[5jxf]], [[5jwi]], [[5jwg]] – PeDPP-XI + polypeptide <br /> | ||
}} | }} | ||
Revision as of 10:06, 1 May 2018
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3D Structures of Dipeptidyl peptidase
Updated on 01-May-2018
References
- ↑ Sakamoto Y, Suzuki Y, Iizuka I, Tateoka C, Roppongi S, Fujimoto M, Inaka K, Tanaka H, Yamada M, Ohta K, Gouda H, Nonaka T, Ogasawara W, Tanaka N. Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity. Sci Rep. 2015 Jun 9;5:11151. doi: 10.1038/srep11151. PMID:26057589 doi:http://dx.doi.org/10.1038/srep11151
- ↑ Pro B, Dang NH. CD26/dipeptidyl peptidase IV and its role in cancer. Histol Histopathol. 2004 Oct;19(4):1345-51. PMID:15375776
- ↑ Barnett A. DPP-4 inhibitors and their potential role in the management of type 2 diabetes. Int J Clin Pract. 2006 Nov;60(11):1454-70. PMID:17073841 doi:10.1111/j.1742-1241.2006.01178.x
- ↑ Itou M, Kawaguchi T, Taniguchi E, Sata M. Dipeptidyl peptidase-4: a key player in chronic liver disease. World J Gastroenterol. 2013 Apr 21;19(15):2298-306. doi:, 10.3748/wjg.v19.i15.2298. PMID:23613622 doi:http://dx.doi.org/10.3748/wjg.v19.i15.2298
- ↑ Furber M, Tiden AK, Gardiner P, Mete A, Ford R, Millichip I, Stein L, Mather A, Kinchin E, Luckhurst C, Barber S, Cage P, Sanganee H, Austin R, Chohan K, Beri R, Thong B, Wallace A, Oreffo V, Hutchinson R, Harper S, Debreczeni J, Breed J, Wissler L, Edman K. Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate. J Med Chem. 2014 Mar 14. PMID:24592859 doi:http://dx.doi.org/10.1021/jm401705g
