Sandbox1014
From Proteopedia
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<scene name='79/792536/Alpha/1'>알파 나선구조</scene> | <scene name='79/792536/Alpha/1'>알파 나선구조</scene> | ||
| + | <scene name='79/792536/Heme_binding/1'>heme biding site</scene> | ||
== Relevance == | == Relevance == | ||
Revision as of 07:42, 18 July 2018
Contents |
Overview
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Cytochrome P450 3A4 (CYP3A4) is in the heme-thiolate monooxygenase enzyme family meaning the protein contains a heme group with an iron atom. Enzymes in Cytochrome P450 are oxidizing enzymes and CYP3A4 works in the body oxidizing foreign molecules such as toxins and drugs[1][2]. It appears almost half of the marketed pharmaceutical drugs are metabolized by CYP3A4 [1] All Cytochrome P450 are essential enzymes for metabolism and the enzyme CYP3A4 is the most important. [2] Primarily found in the liver and intestine, CYP3A4 is localized in the endoplasmic reticulum membrane [3] and are present in all eukaryotic organisms as well as some prokaryotes[3]. While CYP3A4's role in drug metabolism are numerous, they are often aiding deactivation through facilitated excretion from the system or by direct inactivation.
시토크롬P450 3A4(CYP3A4)는 헴-타이오레이트 모노옥시게나아제 효소의 패밀리에 속합니다. 이 패밀리는 철 원자를 가지고 있는 헴 그룹을 포함합니다.adf
Mechanism
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
