Ann Taylor/sandbox Norovirus oligosaccaride binding
From Proteopedia
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The structures in this page are from this paper <ref>DOI: 10.1128/JVI.00219-07</ref> | The structures in this page are from this paper <ref>DOI: 10.1128/JVI.00219-07</ref> | ||
| - | Look at the cartoon view of the virus protein. Is it predominantly alpha helical, beta sheet, or a mixture? | + | Look at the <scene name='81/812829/Secondary_structure/1'>cartoon view</scene> of the virus protein. Is it predominantly alpha helical, beta sheet, or a mixture? |
| - | How many peptide chains make up the quaternary structure? | + | How many peptide chains make up the <scene name='81/812829/Quaternary_structure/1'>quaternary structure?</scene> |
Look at <scene name='81/812829/Interacting_amino_acids/1'>this view</scene> of the carbohydrate (shown in spacefill) interacting with amino acids in the protein (shown as ball and stick). What kind of intermolecular forces help the carbohydrate bind to the protein? | Look at <scene name='81/812829/Interacting_amino_acids/1'>this view</scene> of the carbohydrate (shown in spacefill) interacting with amino acids in the protein (shown as ball and stick). What kind of intermolecular forces help the carbohydrate bind to the protein? | ||
Current revision
Binding of the Norovirus to fucose containing oligosaccarides
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References
- ↑ Hanisch FG, Hansman GS, Morozov V, Kunz C, Schroten H. Avidity of alpha-fucose on human milk oligosaccharides and blood group-unrelated oligo/polyfucoses is essential for potent norovirus-binding targets. J Biol Chem. 2018 Jul 27;293(30):11955-11965. doi: 10.1074/jbc.RA117.001369. Epub, 2018 Jun 1. PMID:29858242 doi:http://dx.doi.org/10.1074/jbc.RA117.001369
- ↑ Cao S, Lou Z, Tan M, Chen Y, Liu Y, Zhang Z, Zhang XC, Jiang X, Li X, Rao Z. Structural basis for the recognition of blood group trisaccharides by norovirus. J Virol. 2007 Jun;81(11):5949-57. Epub 2007 Mar 28. PMID:17392366 doi:10.1128/JVI.00219-07
