Nonstructural protein

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== Structural highlights ==
== Structural highlights ==
<scene name='46/461364/Cv/4'>Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions</scene><ref>PMID:12509436</ref>.
<scene name='46/461364/Cv/4'>Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions</scene><ref>PMID:12509436</ref>.
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== 3D Structures of Nonstructural protein ==
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[[Nonstructural protein 3D structures]]
</StructureSection>
</StructureSection>
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**[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dengue virus<br />
**[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dengue virus<br />
**[[4r05]] – DvNS5 residues 2491-2752 <br />
**[[4r05]] – DvNS5 residues 2491-2752 <br />
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**[[2o1j]] – RvNSP4 diarrhea-inducing domain – Rotavirus<br />
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**[[2o1j]] – RvNSP4 diarrhea-inducing domain – human rotavirus<br />
**[[2gu0]] – RvNS2<br />
**[[2gu0]] – RvNS2<br />
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**[[5y2h]], [[5y2j]], [[5y9r]] – NSP4 diarrhea-inducing domain – bovine rotavirus<br />
**[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
**[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
**[[1fw5]] – NSP1 membrane-binding domain – Semliki forest virus – NMR<br />
**[[1fw5]] – NSP1 membrane-binding domain – Semliki forest virus – NMR<br />

Revision as of 09:05, 11 November 2019

Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu)

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3D Structures of Nonstructural protein

Updated on 11-November-2019

References

  1. Zhu Z, Shi Z, Yan W, Wei J, Shao D, Deng X, Wang S, Li B, Tong G, Ma Z. Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity. PLoS One. 2013;8(2):e55920. doi: 10.1371/journal.pone.0055920. Epub 2013 Feb 6. PMID:23405236 doi:http://dx.doi.org/10.1371/journal.pone.0055920
  2. Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN. Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem. 2003 Mar 14;278(11):9489-95. Epub 2002 Dec 30. PMID:12509436 doi:10.1074/jbc.M209397200

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Michal Harel, Alexander Berchansky

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