Fatty acid synthase

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{{STRUCTURE_3tjm| PDB=3tjm | SIZE=400| SCENE= |right|CAPTION=Human FAS complex with malonyl-CoA, [[3tjm]] }}
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<StructureSection load='3tjm' size='350' side='right' scene='48/484817/Cv/1' caption='Human FAS thioesterase domain complex with fatty acid (PDB code [[3tjm]]) '>
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== Function ==
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'''Fatty acid synthase''' (FAS) catalizes the synthesis of palmitate from acetyl CoA and malonyl CoA into long chain fatty acid<ref>PMID:12689621</ref> . FAS is a multi-domain enzyme. It contains an acyl carrier protein domain (ACP). See also [[Lipid metabolism]].
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'''Fatty acid synthase''' (FAS) catalizes the synthesis of palmitate from acetyl CoA and malonyl CoA into long chain fatty acid. FAS is a multi-domain enzyme. It contains an acyl carrier protein domain (ACP).
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== 3D structures of fatty acid synthase==
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== Relevance ==
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[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br />
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FAS is as target of anti-cancer drugs. FAS from Mycobacterium tuberculosis inhibitors are possible anti-tuberculosis drugs<ref>PMID:30250274</ref> .
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[[1xkt]] – hFAS thioesterase domain – human<br />
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== Structural insights ==
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[[2jfd]] – hFAS MAT domain<br />
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[[3hhd]] - hFAS KS-MAT domain<br />
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[[2cf2]], [[2vz8]] – pFAS – pig<br />
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[[2uv8]], [[3hmj]] – yFAS α+β subunits - yeast<br />
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[[2pff]], [[2was]] – yFAS α subunit<br />
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[[2uv9]] – TlFAS α subunits – ''Thermomyces lanuginosus''<br />
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[[2uva]] – TlFAS β subunits<br />
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[[2png]] – FAS ACP domain – rat<br />
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[[1t8k]] – EcFAS ACP domain - ''Escherichia coli''<br />
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[[2k92]], [[2k93]], [[2k94]] - EcFAS ACP domain – NMR
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'''FAS complex with fatty acid'''
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<scene name='48/484817/Cv/6'>Active site predominantly consists of hydrophobic/non-polar residues</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}). The <scene name='48/484817/Cv/7'>long fatty acid ligand is nestled in a long groove and tunnel</scene><ref>PMID:21908709</ref>.
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[[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br />
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== 3D structures of fatty acid synthase==
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[[1kph]] – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br />
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[[Fatty acid synthase 3D structures]]
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[[1kpi]] – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br />
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[[3hem]] - MtFAS CmaA1 + dioctylamine<br />
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[[3tjm]] – hFAS thioesterase domain + fatty acid<br />
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[[2fae]] – EcFAS ACP domain + decanethioate<br />
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[[2fad]] – EcFAS ACP domain + heptanthioate
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'''FAS complex with reactants'''
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[[2jfk]] – hFAS + malonyl CoA<br />
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[[2uvc]] – TlFAS β subunits + NADP<BR />
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[[2uvb]] – TlFAS α subunits + NADP<BR />
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[[2wat]] – yFAS α subunit + CoA<br />
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[[2vzp]] – pFAS + NADP<BR />
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'''FAS complex with protein'''
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[[2fhs]] – EcFAS ACP domain + enoyl-ACP reductase <br />
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[[3ejb]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme<br />
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[[3ejb]], [[3eje]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid<br />
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[[2cg5]] - hFAS ACP domain + AASD-PPT
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'''FAS complex with inhibitor'''
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</StructureSection>
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[[2vkz]] - yFAS α+β subunits + cerulenin
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human FAS thioesterase domain complex with fatty acid (PDB code 3tjm)

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References

  1. ↑ Smith S, Witkowski A, Joshi AK. Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res. 2003 Jul;42(4):289-317. PMID:12689621
  2. ↑ Elad N, Baron S, Peleg Y, Albeck S, Grunwald J, Raviv G, Shakked Z, Zimhony O, Diskin R. Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 A resolution. Nat Commun. 2018 Sep 24;9(1):3886. doi: 10.1038/s41467-018-06440-6. PMID:30250274 doi:http://dx.doi.org/10.1038/s41467-018-06440-6
  3. ↑ Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-{gamma}-linolenic acid. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15757-62. Epub 2011 Sep 9. PMID:21908709 doi:10.1073/pnas.1112334108

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Michal Harel, Alexander Berchansky

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