Johnson's Monday Lab Sandbox for Insulin Receptor
From Proteopedia
(Difference between revisions)
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==Insulin== | ==Insulin== | ||
| - | + | WHAT IS INSULIN. WHAT DOES IT LOOK LIKE? WHERE IS IT MADE? WHAT DOES IT DO? WHERE DOES IT GO? WHY DO WE NEED IT? | |
==Structure== | ==Structure== | ||
| - | The insulin receptor is a '''heterotetramer''' which resides in the plasma membrane of '''insulin target cells'''. The ectodomain is made up of two alpha subunits and two beta subunits. Each alpha subunit contains two leucine rich domains and a cysteine rich domain. Each beta subunit is made up of three fibronectin type III domains. The insulin receptor extends intracellularly from the beta subunits of the ectodomain by way of a '''transmembrane''' alpha helix. The intracellular domain contains two tyrosine kinase domains. | + | The insulin receptor is a '''heterotetramer''' which resides in the plasma membrane of '''insulin target cells'''. The ectodomain is made up of two alpha subunits and two beta subunits. Each alpha subunit contains two leucine rich domains and a cysteine rich domain. Each beta subunit is made up of three fibronectin type III domains. The insulin receptor extends intracellularly from the beta subunits of the ectodomain by way of a '''transmembrane''' alpha helix. The intracellular domain contains two tyrosine kinase domains. NEED TO DISCUSS V VS T SHAPE. OVERLAPPING OF HOMODIMERS. C TERM ALPHA HELIX. COVALENT DISULFIDE BONDS |
===How Insulin Binds=== | ===How Insulin Binds=== | ||
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===Conformational Changes=== | ===Conformational Changes=== | ||
| + | STABLIZING INTERACTIONS. HOW DOES THE SHAPE CHANGE? WHEN IS CHANGE DRASTIC? | ||
==Type II Diabetes== | ==Type II Diabetes== | ||
| - | + | WHAT IS T2D? HOW DOES IT RELATE TO THE INSULIN RECEPTOR? WHAT DOES A NON T2D SYSTEM LOOK LIKE? HOW DOES IT COMPARE TO T1D? WHY IS THIS IMPORTANT? | |
== References == | == References == | ||
<ref name="Uchikawa"> DOI:10.7554/eLife.48630</ref> | <ref name="Uchikawa"> DOI:10.7554/eLife.48630</ref> | ||
Revision as of 03:10, 23 March 2020
Insulin Receptor
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