Johnson's Monday Lab Sandbox for Insulin Receptor
From Proteopedia
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It was found that at least three insulin molecules would have to bind to the receptor for the receptor to take on its active “T-state” conformation <ref name="Uchikawa" />. The difference between the fully bound state with four insulins and the three insulin bound state is minimal compared to the difference between two and three insulins bound <ref name="Uchikawa" />. | It was found that at least three insulin molecules would have to bind to the receptor for the receptor to take on its active “T-state” conformation <ref name="Uchikawa" />. The difference between the fully bound state with four insulins and the three insulin bound state is minimal compared to the difference between two and three insulins bound <ref name="Uchikawa" />. | ||
| - | The insulin molecules in site 1 and 1' have their main interactions with an <scene name='83/839263/Insulin_bound_to_site_1/2'>alpha helix</scene> in the insulin receptor. The insulin molecules are shown in green and the insulin receptor is shown in orange. | + | The insulin molecules in site 1 and 1' have their main interactions with an <scene name='83/839263/Insulin_bound_to_site_1/2'>alpha helix</scene> in the insulin receptor. The insulin molecules are shown in green and the insulin receptor is shown in orange. The insulin molecules in site 2 and 2' have their main interactions with the residues that comprise some of the <scene name='83/839263/Insulin_in_site_2_with_beta_sh/3'>beta-sheets</scene> of the insulin receptor. The red molecules are insulin and the yellow is the beta sheets of the insulin receptor. |
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| - | The insulin molecules in site 2 and 2' have their main interactions with the residues that comprise some of the <scene name='83/839263/Insulin_in_site_2_with_beta_sh/3'>beta-sheets</scene> of the insulin receptor. The red molecules are insulin and the yellow is the beta sheets of the insulin receptor. | + | |
===Conformational Changes=== | ===Conformational Changes=== | ||
Revision as of 19:05, 23 March 2020
Insulin Receptor
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