Johnson's Monday Lab Sandbox for Insulin Receptor
From Proteopedia
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==Function of the Receptor== | ==Function of the Receptor== | ||
| - | The insulin receptor serves as the gateway for regulation of various cellular processes. These processes include but are not limited to glucose transport, glycogen storage, autophagy, apoptosis, and gene expression. Additionally, the insulin receptor has been associated with the development of diseases such as Alzheimer's, Type II Diabetes, and cancer <ref name="Scapin" />. Characterization of the structure of the insulin receptor as well as understanding of the molecular mechanisms which initiate a conformational change are important for understanding the role that the insulin receptor plays within a cell and in the development of disease. | + | The insulin receptor serves as the gateway for the regulation of various cellular processes. These processes include but are not limited to glucose transport, glycogen storage, autophagy, apoptosis, and gene expression. Additionally, the insulin receptor has been associated with the development of diseases such as Alzheimer's, Type II Diabetes, and cancer <ref name="Scapin" />. Characterization of the structure of the insulin receptor as well as understanding of the molecular mechanisms which initiate a conformational change are important for understanding the role that the insulin receptor plays within a cell and in the development of disease. |
==Insulin== | ==Insulin== | ||
WHAT IS INSULIN. WHAT DOES IT LOOK LIKE? WHERE IS IT MADE? WHAT DOES IT DO? WHERE DOES IT GO? WHY DO WE NEED IT? | WHAT IS INSULIN. WHAT DOES IT LOOK LIKE? WHERE IS IT MADE? WHAT DOES IT DO? WHERE DOES IT GO? WHY DO WE NEED IT? | ||
==Structure== | ==Structure== | ||
| - | The insulin receptor is a [http://en.wikipedia.org/wiki/ | + | The insulin receptor is a [http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase] heterotetramer which resides in the plasma membrane of insulin [http://en.wiktionary.org/wiki/target_cell target cell]. The ectodomain is made up of two alpha subunits and two beta subunits. Each alpha subunit contains two leucine-rich domains and a cysteine-rich domain. Each beta subunit is made up of three fibronectin type III domains. The insulin receptor extends intracellularly from the beta subunits of the ectodomain by way of a [http://en.wikipedia.org/wiki/Transmembrane_protein transmembrane] alpha helix. The intracellular domain contains two tyrosine kinase domains. NEED TO DISCUSS V VS T SHAPE. OVERLAPPING OF HOMODIMERS. C TERM ALPHA HELIX. COVALENT DISULFIDE BONDS |
===Insulin Binding=== | ===Insulin Binding=== | ||
Revision as of 19:21, 23 March 2020
Insulin Receptor
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