User:Milena Ortiz Ribeiro/Sandbox 1
From Proteopedia
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== Function == | == Function == | ||
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<ref>TONOLLI, P.N. <i> O papel do fator de transcrição mitocondrial A na proteção do DNA mitocondrial contra lesões oxidadas.</i> São Paulo. 2013. </ref> | <ref>TONOLLI, P.N. <i> O papel do fator de transcrição mitocondrial A na proteção do DNA mitocondrial contra lesões oxidadas.</i> São Paulo. 2013. </ref> | ||
<ref>PMID: 32371956 </ref> | <ref>PMID: 32371956 </ref> | ||
| - | <ref>PMID: 27448789 </ref> | ||
<ref>PMID: 31419493 </ref> | <ref>PMID: 31419493 </ref> | ||
== Disease == | == Disease == | ||
| - | A positive relationship is reported between mDNA copy number, glucose consumption and ATP production in melanoma cells. | + | A positive relationship is reported between mDNA copy number, glucose consumption and ATP production in melanoma cells. <ref>PMID: 30242167 </ref> In addition, a new hepatocerebral mtDNA depletion syndrome caused by TFAM deficiency is presented in the literature. The disease is characterized due to liver failure from neonatal onset progressing to death. Liver pathology revealed cirrhosis, steatosis, cholestasis and mitochondrial changes. It was observed that mtDNA is depleted in the liver and skeletal muscles and provides evidence that this results in decreased expression of the TFAM protein, reduced drial function and nucleoid formation.<ref>PMID: 27448789 </ref> |
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== Relevance == | == Relevance == | ||
Revision as of 19:15, 15 June 2020
Your Heading Here (maybe something like 'Structure')
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References
- ↑ TONOLLI, P.N. O papel do fator de transcrição mitocondrial A na proteção do DNA mitocondrial contra lesões oxidadas. São Paulo. 2013.
- ↑ Liu Y, Jin M, Wang Y, Zhu J, Tan R, Zhao J, Ji X, Jin C, Jia Y, Ren T, Xing J. MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth. Signal Transduct Target Ther. 2020 May 5;5(1):59. doi: 10.1038/s41392-020-0155-5. PMID:32371956 doi:http://dx.doi.org/10.1038/s41392-020-0155-5
- ↑ Kozhukhar N, Alexeyev MF. Limited predictive value of TFAM in mitochondrial biogenesis. Mitochondrion. 2019 Nov;49:156-165. doi: 10.1016/j.mito.2019.08.001. Epub 2019, Aug 13. PMID:31419493 doi:http://dx.doi.org/10.1016/j.mito.2019.08.001
- ↑ Araujo LF, Siena ADD, Placa JR, Brotto DB, Barros II, Muys BR, Biagi CAO Jr, Peronni KC, Sousa JF, Molfetta GA, West LC, West AP, Leopoldino AM, Espreafico EM, Silva WA Jr. Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma. Sci Rep. 2018 Sep 21;8(1):14190. doi: 10.1038/s41598-018-31170-6. PMID:30242167 doi:http://dx.doi.org/10.1038/s41598-018-31170-6
- ↑ Stiles AR, Simon MT, Stover A, Eftekharian S, Khanlou N, Wang HL, Magaki S, Lee H, Partynski K, Dorrani N, Chang R, Martinez-Agosto JA, Abdenur JE. Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion. Mol Genet Metab. 2016 Sep;119(1-2):91-9. doi: 10.1016/j.ymgme.2016.07.001. Epub, 2016 Jul 4. PMID:27448789 doi:http://dx.doi.org/10.1016/j.ymgme.2016.07.001
