1bso

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[[Image:1bso.gif|left|200px]]
[[Image:1bso.gif|left|200px]]
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{{Structure
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|PDB= 1bso |SIZE=350|CAPTION= <scene name='initialview01'>1bso</scene>, resolution 2.23&Aring;
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The line below this paragraph, containing "STRUCTURE_1bso", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BRC:12-BROMODODECANOIC+ACID'>BRC</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_1bso| PDB=1bso | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bso OCA], [http://www.ebi.ac.uk/pdbsum/1bso PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bso RCSB]</span>
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}}
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'''12-BROMODODECANOIC ACID BINDS INSIDE THE CALYX OF BOVINE BETA-LACTOGLOBULIN'''
'''12-BROMODODECANOIC ACID BINDS INSIDE THE CALYX OF BOVINE BETA-LACTOGLOBULIN'''
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[[Category: Jameson, G B.]]
[[Category: Jameson, G B.]]
[[Category: Qin, B Y.]]
[[Category: Qin, B Y.]]
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[[Category: beta-lactoglobulin]]
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[[Category: Beta-lactoglobulin]]
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[[Category: ligand binding]]
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[[Category: Ligand binding]]
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[[Category: x-ray crystal structure]]
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[[Category: X-ray crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:54:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:07:34 2008''
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Revision as of 08:54, 2 May 2008

Image:1bso.gif

Template:STRUCTURE 1bso

12-BROMODODECANOIC ACID BINDS INSIDE THE CALYX OF BOVINE BETA-LACTOGLOBULIN


Overview

The X-ray structure of bovine beta-lactoglobulin with the ligand 12-bromododecanoic acid as a model for fatty acids has been determined at a resolution of 2.23 A in the trigonal lattice Z form. The ligand binds inside the calyx, resolving a long-standing controversy as to where fatty-acid like ligands bind. The carboxylate head group lies at the surface of the molecule, and the lid to the calyx is open at the pH of crystallization (pH 7.3), consistent with the conformation observed in ligand-free bovine beta-lactoglobulin in lattice Z at pH 7.1 and pH 8.2.

About this Structure

1BSO is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

12-Bromododecanoic acid binds inside the calyx of bovine beta-lactoglobulin., Qin BY, Creamer LK, Baker EN, Jameson GB, FEBS Lett. 1998 Nov 6;438(3):272-8. PMID:9827560 Page seeded by OCA on Fri May 2 11:54:38 2008

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