Cancer
From Proteopedia
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[[Cancer]] is a class of diseases marked by uncontrolled cellular growth resulting in intrusion on and destruction of adjacent tissues, while often spreading to other locations in the body via the lymphatic or circulatory systems. | [[Cancer]] is a class of diseases marked by uncontrolled cellular growth resulting in intrusion on and destruction of adjacent tissues, while often spreading to other locations in the body via the lymphatic or circulatory systems. | ||
| - | {{#tree:id=CancerTopic|openlevels= | + | {{#tree:id=CancerTopic|openlevels=1| |
Articles in Proteopedia concerning [[Cancer]] include: | Articles in Proteopedia concerning [[Cancer]] include: | ||
*[[8-Oxoguanine Glycosylase]] | *[[8-Oxoguanine Glycosylase]] | ||
*[[Antizyme Inhibitor]] | *[[Antizyme Inhibitor]] | ||
| + | *[[Aromatase]] | ||
| + | *The levels of [[Arylamine N-acetyltransferase]] in the body has important consequences with regard to an individual’s susceptibility to certain drug-induced toxicities and cancer. Acetylation is a major route of biotransformation for many arylamines and hydrazine drugs and known carcinogens like cigarette smoke. | ||
*Caspases | *Caspases | ||
**[[Molecular_Playground/Caspase-6|Caspase-6]] | **[[Molecular_Playground/Caspase-6|Caspase-6]] | ||
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*[[6-deoxyerythronolide_B_synthase_%28DEBS%29|DEBS]] | *[[6-deoxyerythronolide_B_synthase_%28DEBS%29|DEBS]] | ||
*[[Dihydrofolate_reductase|Dihydrofolate Reductase, the Target of Methotrexate]] | *[[Dihydrofolate_reductase|Dihydrofolate Reductase, the Target of Methotrexate]] | ||
| + | *[[Estrogen receptor]] | ||
| + | *[[Forkhead box protein M1]] | ||
*Growth Factors & Receptors | *Growth Factors & Receptors | ||
| - | ** | + | **[[Growth factors|Growth Factors & Receptors]] |
| - | ***[[ | + | **[[Autocrine motility factor]] |
| - | **[[ | + | **[[Bone morphogenetic protein]] |
| - | **[[ | + | **[[Colony-stimulating factor]] |
| - | ** | + | **[[Epidermal growth factor]] and [[Epidermal Growth Factor Receptor]] |
| - | ***[[Insulin- | + | **[[Ephrin]] and [[Ephrin receptor]] |
| - | ***[[ | + | **[[Fibroblast growth factor]] and [[Fibroblast growth factor receptor]] |
| - | ** | + | **[[Growth differentiation factor]] |
| - | ***[[ | + | **[[Hepatocyte growth factor]] and [[Hepatocyte growth factor receptor]] |
| - | ***[[Vascular Endothelial Growth Factor Receptor]] | + | **[[Insulin-like growth factor]] and [[Insulin-like growth factor receptor]] |
| + | ***[[IGF1]] | ||
| + | **[[Interleukin]] | ||
| + | **[[Platelet-derived growth factors and receptors]] | ||
| + | **[[Tumor necrosis factor]] | ||
| + | ***[[Tumor necrosis factor receptor]] | ||
| + | ***[[Tumor necrosis factor ligand superfamily]] | ||
| + | **[[Vascular Endothelial Growth Factor]] and [[Vascular Endothelial Growth Factor Receptor]] | ||
*[[User:Yash_Patankar/Sandbox_1|Heat Shock Protein 90]] | *[[User:Yash_Patankar/Sandbox_1|Heat Shock Protein 90]] | ||
| - | *[[ | + | *[[Hypoxia-Inducible_Factors|Hypoxia Inducible Factor (HIF)]] |
*[[1ebm|Human 8-Oxoguanine Glycosylase Structure and Mechanism (HOGG1)]] | *[[1ebm|Human 8-Oxoguanine Glycosylase Structure and Mechanism (HOGG1)]] | ||
| + | *[[Isocitrate dehydrogenase]] | ||
*Kinases | *Kinases | ||
**[[Cyclin Dependent Kinase-4]] | **[[Cyclin Dependent Kinase-4]] | ||
| - | **[[ | + | **[[Phosphoinositide 3-Kinases]] |
| - | **[[ | + | **[[Bcr-Abl_and_Imatinib_%28STI571_or_Gleevec%29]] |
| + | **[[Receptor tyrosine kinases]] | ||
**Mitogen-Activated Proteins | **Mitogen-Activated Proteins | ||
| - | ***Mitogen- | + | ***[[Mitogen-activated protein kinase]] |
| - | ***Mitogen- | + | ***[[Mitogen-activated protein kinase kinase]] |
| - | ***Mitogen- | + | ***[[Mitogen-activated protein kinase kinase kinase]] |
*Oncogenes | *Oncogenes | ||
**[[C-Myc]] - Proto-Oncogenic Gene | **[[C-Myc]] - Proto-Oncogenic Gene | ||
| - | **[[ | + | **[[MDM2]] |
**[[P53]] - Tumor Suppressing Gene | **[[P53]] - Tumor Suppressing Gene | ||
**[[Nathan_Line_sandbox|PTEN]] | **[[Nathan_Line_sandbox|PTEN]] | ||
**[[SRC]] - Proto-Oncogenic Tyrosine Kinase Gene | **[[SRC]] - Proto-Oncogenic Tyrosine Kinase Gene | ||
| - | *[[P-glycoprotein:_Why_Cancer_Drugs_Fail|P-Glycoprotein: Why Cancer Drugs Fail]] | ||
*[[Ann_Taylor_sandbox_Proteins_in_Cancer|Proteins in Cancer]] | *[[Ann_Taylor_sandbox_Proteins_in_Cancer|Proteins in Cancer]] | ||
*[[Ras|The Ras Superfamily]] | *[[Ras|The Ras Superfamily]] | ||
*[[Chad Sorenson sandbox 1|Retinoblastoma Protein]] | *[[Chad Sorenson sandbox 1|Retinoblastoma Protein]] | ||
*[[Sonic Hedgehog]] | *[[Sonic Hedgehog]] | ||
| - | *[[Molecular_Playground/Taxol|Taxol Information]] | + | *[[Tamoxifen]] |
| + | *Taxol | ||
| + | **[[Paclitaxel]] | ||
| + | **[[Molecular_Playground/Taxol|Taxol Information]] | ||
*[[Telomerase Reverse Transcriptase]] | *[[Telomerase Reverse Transcriptase]] | ||
*[[User:Sarah Abdalla/Thioredoxin Reductase|Thioredoxin Reductase]] | *[[User:Sarah Abdalla/Thioredoxin Reductase|Thioredoxin Reductase]] | ||
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To view [[Cancer]] related proteins which are [[Proteopedia:Structure Index|Structure Index]] entries see: | To view [[Cancer]] related proteins which are [[Proteopedia:Structure Index|Structure Index]] entries see: | ||
| + | *[[Epidermal_Growth_Factor_Receptor#3D_Structures_of_Epidermal_Growth_Factor_Receptor|Endothelial Growth Factor Receptor]] | ||
| + | *[[Phosphoinositide_3-Kinase#Additional_3D_Structures|Phosphoinositide 3-Kinase]] | ||
*[[VEGF#Additional_3D_Structures_of_VEGF|Vascular Endothelial Growth Factor]] | *[[VEGF#Additional_3D_Structures_of_VEGF|Vascular Endothelial Growth Factor]] | ||
*[[VEGFR#Additional_3D_Structures_of_VEGFR|Vascular Endothelial Growth Factor Receptor]] | *[[VEGFR#Additional_3D_Structures_of_VEGFR|Vascular Endothelial Growth Factor Receptor]] | ||
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*[[:Category:Cancer therapeutic|Cancer Therapeutic]] | *[[:Category:Cancer therapeutic|Cancer Therapeutic]] | ||
<br /> | <br /> | ||
| + | |||
| + | To View FDA Approved Treatments for [[Cancer]] See: [[Pharmaceutical_Drugs#Treatments|Treatments]] | ||
To view other Proteopedia pages about diseases & drug targets, See: [[Pharmaceutical_Drug_Targets|Pharmaceutical Drug Targets]] | To view other Proteopedia pages about diseases & drug targets, See: [[Pharmaceutical_Drug_Targets|Pharmaceutical Drug Targets]] | ||
Current revision
Cancer is a class of diseases marked by uncontrolled cellular growth resulting in intrusion on and destruction of adjacent tissues, while often spreading to other locations in the body via the lymphatic or circulatory systems.
Articles in Proteopedia concerning Cancer include:
To view Cancer related proteins which are Structure Index entries see:
- Endothelial Growth Factor Receptor
- Phosphoinositide 3-Kinase
- Vascular Endothelial Growth Factor
- Vascular Endothelial Growth Factor Receptor
To view automatically seeded indices concerning Cancer See:
To View FDA Approved Treatments for Cancer See: Treatments
To view other Proteopedia pages about diseases & drug targets, See: Pharmaceutical Drug Targets
Proteopedia Page Contributors and Editors (what is this?)
David Canner, Alexander Berchansky, Gonzalo Garcia-Martin, Jaime Prilusky, Wayne Decatur
