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Ceramide

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(New page: <StructureSection load='' scene='Acid-beta-glucosidase/Overview2/2' size='350' caption='Human acid-β-glucosidase (PDB code 1ogs)' > This is a default text for your page '''Ceramide''...)
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<StructureSection load='' scene='Acid-beta-glucosidase/Overview2/2' size='350' caption='Human acid-β-glucosidase (PDB code [[1ogs]])'
<StructureSection load='' scene='Acid-beta-glucosidase/Overview2/2' size='350' caption='Human acid-β-glucosidase (PDB code [[1ogs]])'
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This is a default text for your page '''Ceramide'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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*[[Sphingomyelinase]] (SMase) or sphingomyelin phosphodiesterase is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide<ref>PMID:11001563</ref>.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Function ==
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*[[Acid-beta-glucosidase]] or '''glucosylceramidase''' is a lysozomal enzyme (EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45]), which cleaves glucosylceramide to glucose and ceramide. It catalyzes hydrolysis of the sphingolipid, <scene name='Acid-beta-glucosidase/Cv/3'>glucosylceramide (GlcCer)</scene>, to <scene name='Acid-beta-glucosidase/Cv/2'>glucose and ceramide</scene> at the acidic pH prevailing within the lysosome. <scene name='Acid-beta-glucosidase/Cv/4'>Click here to see animation of this reaction</scene>.
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*The molecular function of [[galactosylceramidase]] is hydrolysis of a O-glycosyl bond to remove galactose from ceramide and other sphingolipids.
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== Disease ==
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== Relevance ==
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== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Revision as of 15:00, 5 December 2021

Human acid-β-glucosidase (PDB code 1ogs)

Drag the structure with the mouse to rotate

References

  1. ↑ Chatterjee S. Neutral sphingomyelinase: past, present and future. Chem Phys Lipids. 1999 Nov;102(1-2):79-96. PMID:11001563

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky

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