Journal:Acta Cryst F:S2053230X21013595
From Proteopedia
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Giardiasis or traveler's diarrhea can be fatal to the young, elderly, or immunocompromised. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of potential drug targets from ''Giardia lamblia''. Some of these proteins are hypothetical proteins that share < 30% sequence identity or less to proteins with known structure (see static image below). | Giardiasis or traveler's diarrhea can be fatal to the young, elderly, or immunocompromised. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of potential drug targets from ''Giardia lamblia''. Some of these proteins are hypothetical proteins that share < 30% sequence identity or less to proteins with known structure (see static image below). | ||
| - | [[Image:Figure3newa.png|left|450px|thumb|Despite the low sequence similarity the hypothetical protein is a prototypical YjgF/YER057c/UK114 | + | [[Image:Figure3newa.png|left|450px|thumb|Despite the low sequence similarity the hypothetical protein is a prototypical YjgF/YER057c/UK114 endoribonuclease]] |
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The atomic resolution structure of a 15.6 kDa protein was determined by molecular replacement (PDB entry [[3i3f]]). The structure has <scene name='90/900077/Cv/6'>the 2-layer alpha-beta-sandwich topology</scene> observed in the prototypical endoribonucleases L-PSP with conserved allosteric active sites containing small molecules from the crystallization solution. {{Template:ColorKey_Helix}}, | The atomic resolution structure of a 15.6 kDa protein was determined by molecular replacement (PDB entry [[3i3f]]). The structure has <scene name='90/900077/Cv/6'>the 2-layer alpha-beta-sandwich topology</scene> observed in the prototypical endoribonucleases L-PSP with conserved allosteric active sites containing small molecules from the crystallization solution. {{Template:ColorKey_Helix}}, | ||
Revision as of 10:58, 10 January 2022
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This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
