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SpikeProteinStructureHZ
From Proteopedia
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| - | ==Sars-CoV-2 Spike Protein Structure | + | ==Sars-CoV-2 Spike Protein Structure 02.02.2022 (Hong Y. Zhai)== |
<StructureSection load='6vyb' size='680' side='right' caption='Proteopedia SpikeProteinStructureHZ 02.02.22 scene=''> | <StructureSection load='6vyb' size='680' side='right' caption='Proteopedia SpikeProteinStructureHZ 02.02.22 scene=''> | ||
Displaying the mutated structure on SARS-COV-2 viral particle's spike protein, based on entry: '6vyb'. | Displaying the mutated structure on SARS-COV-2 viral particle's spike protein, based on entry: '6vyb'. | ||
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<scene name='90/903492/Ov_new_mutations/1'>Mutations @214 @371 @505 @764 were highlighted</scene>. | <scene name='90/903492/Ov_new_mutations/1'>Mutations @214 @371 @505 @764 were highlighted</scene>. | ||
| + | Click the green text to bring up the fine structure: the newly acquired mutations, are located in the "interfacing" zone: upon cell entry, spots viral particle motifs contact ACE2. | ||
| - | + | We also provide another enhanced structural illustration below: | |
| + | |||
| + | [[Image:SPG_Substructure_6VSB_new_mutations_Small.png]] | ||
| + | |||
| + | Full resolution can be found here | ||
| + | https://proteopedia.org/wiki/index.php/Image:SPG_Substructure_6VSB_new_mutations.png | ||
== Function == | == Function == | ||
| - | Cell entry | + | Cell entry: Here is a simple demonstration that the newly acquired mutations in Omicron variant (OV) are located in the "interfacing" zone. |
== Disease == | == Disease == | ||
| - | CoV-19 Disease Antigen co-conspirator | + | CoV-19 Disease Antigen co-conspirator: the OV's general fitness has a root cause, as we discussed. |
== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
| - | + | SARS-CoV-2 Spike Protein with 4 highlighted OV mutations. | |
</StructureSection> | </StructureSection> | ||
| + | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Sars-CoV-2 Spike Protein Structure 02.02.2022 (Hong Y. Zhai)
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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
