One-carbon metabolism
From Proteopedia
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== Further reading == | == Further reading == | ||
* Origin of methyl groups in the pathway<ref>PMID:23822983</ref> | * Origin of methyl groups in the pathway<ref>PMID:23822983</ref> | ||
| + | * Vision changes after spaceflight<ref>DOI:0.3945/jn.111.154245</ref> | ||
== References == | == References == | ||
Revision as of 13:54, 6 March 2022
This article is a work in process during the Spring 2022 semester.
One-carbon metabolism refers to biochemical pathways that transfer a single carbon. Typically, these reactions are catalyzed by enzymes using cofactors or prosthetic groups such as S-adenosyl methionine, tetrahydrofolate, cobalamin or biotin, many of which are vitamin-derived[1]. The transfered carbon may have various oxidation states and end up as different functional groups such as methyl, methenyl, formyl, or carboxylate. One-carbon transfer reactions play a role in amino acid and nucleid acid biosynthesis, in epigenetics and cellular redox status [2].
Further reading
References
- ↑ Li K, Wahlqvist ML, Li D. Nutrition, One-Carbon Metabolism and Neural Tube Defects: A Review. Nutrients. 2016 Nov 23;8(11). pii: nu8110741. doi: 10.3390/nu8110741. PMID:27886045 doi:http://dx.doi.org/10.3390/nu8110741
- ↑ Ducker GS, Rabinowitz JD. One-Carbon Metabolism in Health and Disease. Cell Metab. 2017 Jan 10;25(1):27-42. doi: 10.1016/j.cmet.2016.08.009. Epub 2016, Sep 15. PMID:27641100 doi:http://dx.doi.org/10.1016/j.cmet.2016.08.009
- ↑ Locasale JW. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer. 2013 Aug;13(8):572-83. doi: 10.1038/nrc3557. Epub 2013 Jul 4. PMID:23822983 doi:http://dx.doi.org/10.1038/nrc3557
- ↑ doi: https://dx.doi.org/0.3945/jn.111.154245
