Talk:Methionine synthase
From Proteopedia
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compare {2.1} {1.1} SUBSET{*.CA} ATOMS{800-900}{800-900} ROTATE TRANSLATE | compare {2.1} {1.1} SUBSET{*.CA} ATOMS{800-900}{800-900} ROTATE TRANSLATE | ||
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| + | This is a cartoon of the domain structure: https://www.researchgate.net/profile/Rowena-Matthews/publication/274991544/figure/fig7/AS:294958637568000@1447335027092/Modular-structure-of-cobalamin-dependent-methionine-synthase-MetH-the-metH-gene_W640.jpg | ||
</StructureSection> | </StructureSection> | ||
<references/> | <references/> | ||
Revision as of 21:05, 4 April 2022
There is a related protein where the entire structure was solved:
If you don't want to watch the entire thing, skip ahead to 31:20
The paper is here.[1]
This has the N-terminal half of the protein, including the homocysteine binding domain.[2]
Some methionine synthases don't make use of the folate cycle.[3]
Predicted entire structure
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- ↑ Kung Y, Ando N, Doukov TI, Blasiak LC, Bender G, Seravalli J, Ragsdale SW, Drennan CL. Visualizing molecular juggling within a B(12)-dependent methyltransferase complex. Nature. 2012 Mar 14. doi: 10.1038/nature10916. PMID:22419154 doi:10.1038/nature10916
- ↑ Koutmos M, Pejchal R, Bomer TM, Matthews RG, Smith JL, Ludwig ML. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3286-91. Epub 2008 Feb 22. PMID:18296644
- ↑ doi: https://dx.doi.org/10.1371/journal.pgen.100934
