Talk:Methionine synthase
From Proteopedia
(Difference between revisions)
(New page: There is a related protein where the entire structure was solved: If you don't want to watch the entire thing, skip ahead to 31:20 <html5media height="300" width="300">https://www.youtub...) |
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| + | Here is the PDF of a review on B12 enabled reactions: [https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1458&context=biochemfacpub] | ||
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There is a related protein where the entire structure was solved: | There is a related protein where the entire structure was solved: | ||
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The paper is here.<ref>DOI:10.1038/nature10916</ref> | The paper is here.<ref>DOI:10.1038/nature10916</ref> | ||
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| + | This has the N-terminal half of the protein, including the homocysteine binding domain.<ref>PMID:18296644</ref> | ||
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| + | Reactivation: DOI:10.1073/pnas.0906132106 | ||
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| + | Some methionine synthases don't make use of the folate cycle. | ||
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| + | ==Predicted entire structure== | ||
| + | <StructureSection load='1k7y' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry [[3rec]])' scene=''> | ||
| + | And this is the <scene name='90/907476/Predicted/1'>alphafold prediction</scene> of the entire structure. | ||
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| + | load append =3iva | ||
| + | compare {2.1} {1.1} SUBSET{*.CA} ATOMS{800-900}{800-900} ROTATE TRANSLATE | ||
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| + | This is a cartoon of the domain structure: https://www.researchgate.net/profile/Rowena-Matthews/publication/274991544/figure/fig7/AS:294958637568000@1447335027092/Modular-structure-of-cobalamin-dependent-methionine-synthase-MetH-the-metH-gene_W640.jpg | ||
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| + | </StructureSection> | ||
<references/> | <references/> | ||
Current revision
Here is the PDF of a review on B12 enabled reactions: [1]
There is a related protein where the entire structure was solved:
If you don't want to watch the entire thing, skip ahead to 31:20
The paper is here.[1]
This has the N-terminal half of the protein, including the homocysteine binding domain.[2]
Reactivation: DOI:10.1073/pnas.0906132106
Some methionine synthases don't make use of the folate cycle.
Predicted entire structure
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- ↑ Kung Y, Ando N, Doukov TI, Blasiak LC, Bender G, Seravalli J, Ragsdale SW, Drennan CL. Visualizing molecular juggling within a B(12)-dependent methyltransferase complex. Nature. 2012 Mar 14. doi: 10.1038/nature10916. PMID:22419154 doi:10.1038/nature10916
- ↑ Koutmos M, Pejchal R, Bomer TM, Matthews RG, Smith JL, Ludwig ML. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3286-91. Epub 2008 Feb 22. PMID:18296644
