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3v69
From Proteopedia
(Difference between revisions)
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==Filia-N crystal structure== | ==Filia-N crystal structure== | ||
| - | <StructureSection load='3v69' size='340' side='right' caption='[[3v69]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='3v69' size='340' side='right'caption='[[3v69]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3v69]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3v69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V69 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BL6 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BL6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v69 OCA], [https://pdbe.org/3v69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v69 RCSB], [https://www.ebi.ac.uk/pdbsum/3v69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v69 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KHDC3_MOUSE KHDC3_MOUSE]] Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.<ref>PMID:19376971</ref> <ref>PMID:22276159</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Li, L]] | [[Category: Li, L]] | ||
Revision as of 08:34, 20 July 2022
Filia-N crystal structure
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Categories: Large Structures | Lk3 transgenic mice | Li, L | Liu, X | Wang, J | Xu, M | Zhu, K | Embryogenesis | Filia | Kh domain | Protein binding | Rna binding | Rna-binding
