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Polycomb proteins
From Proteopedia
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== Function == | == Function == | ||
| - | Polycomb group (PcG) proteins are determinants of gene silencing and epigenetic memory in higher eukaryotes. The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures. The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth<ref>PMID:27705803</ref>. | + | '''Polycomb group (PcG) proteins''' are determinants of gene silencing and epigenetic memory in higher eukaryotes. The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures. The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth<ref>PMID:27705803</ref>. For the '''B'''-cell-specific '''M'''olony leukemia virus '''I'''nsertion site '''1''' (BMI1) see [[BMI1]]. |
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| + | See also: [[Polycomb complex protein]]. | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of polycomb proteins== | ==3D structures of polycomb proteins== | ||
| + | [[Polycomb complex proteins 3D structures]] | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Polycomb BMI1 | ||
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| - | **[[5fr6]] - hPcG - human<br /> | ||
| - | **[[3rpg]] - hPcG + RING1B + Ubch5C<br /> | ||
| - | **[[4r8p]] - hPcG + RING1B + Ubch5C + histones + DNA<br /> | ||
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| - | *Polycomb EED | ||
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| - | **[[5wf7]], [[5bjs]], [[5vk3]] - CtPcG + EZH2/PcG SUZ12 - ''Chaetomium thermophilum''<br /> | ||
| - | **[[5wfd]] - CtPcG + zinc finger containing protein + inhibitor<br /> | ||
| - | **[[5wfc]] - CtPcG (mutant) + EZH2/PcG SUZ12 + histone peptide + inhibitor<br /> | ||
| - | **[[5tqr]] - CtPcGCP + EZH2/PCP SUZ12 + SAM<br /> | ||
| - | **[[3jzn]] - hPcG <br /> | ||
| - | **[[5wg6]] - hPcG + EZH2 <br /> | ||
| - | **[[5ij7]], [[5ij8]], [[4w2r]], [[6b3w]] - hPcG + EZH2 + PcG SUZ12 + inhibitor<br /> | ||
| - | **[[5ij8]] - hPcG + EZH2 + PcG SUZ12 + inhibitor<br /> | ||
| - | **[[5ls6]] - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3 <br /> | ||
| - | **[[5hyn]] - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3 + histone peptide<br /> | ||
| - | **[[6c23]], [[6c24]] - hPcG + EZH2 + PcG SUZ12 + Jarid2 substrate + Jumonji + SUZ12 + RBBP4 - Cryo EM<br /> | ||
| - | **[[4x3e]] - hPcG + Jarid2 peptide <br /> | ||
| - | **[[3jpx]], [[3iiw]], [[3iiy]], [[3ij0]], [[3ij1]], [[3jzg]], [[3jzh]], [[3k26]],[[5fr6]] - hPcG <br /> | ||
| - | **[[5u69]], [[5u6d]], [[5u8a]], [[5k0m]], [[5h13]], [[5u5h]], [[5u5k]], [[5u8f]] - hPcG + inhibitor <br /> | ||
| - | **[[3ijc]] - hPcG (mutant) + inhibitor <br /> | ||
| - | **[[5wp3]] - hPcG + EB22 <br /> | ||
| - | **[[5ttw]] - hPcG + UNC4859 <br /> | ||
| - | **[[5h14]], [[5h15]], [[5h17]], [[5h19]], [[5u5t]], [[5u62]], [[5h25]], [[5gsa]], [[5h24]], [[5wuk]] - hPcG + EZH2 + inhibitor <br /> | ||
| - | **[[1pdq]], [[1pfb]] - DmPcG chromodomain + histone peptide - ''Drosophila melanogaster''<br /> | ||
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| - | *Polycomb SUZ12 | ||
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| - | **[[5wak]] - hPcG + RBBP4 <br /> | ||
| - | **[[5wai]] - hPcG + RBBP4 + Jarid2 + AEPB2 <br /> | ||
| - | **[[2yb8]] - DmPcG + CAF1<br /> | ||
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| - | *Polycomb SCMH1 | ||
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| - | **[[2p0k]] - hPcG <br /> | ||
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| - | *Polycomb SFMBT | ||
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| - | **[[4c5e]], [[4c5g]], [[4c5h]] - DmPcG + PcG PHO <br /> | ||
| - | **[[5j8y]] - DmPcG + PcG SCM <br /> | ||
| - | **[[3h6z]] - DmPcG + histone peptide <br /> | ||
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| - | *Polycomb PCL | ||
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| - | **[[2xk0]] - DmPcG tudor domain - NMR <br /> | ||
| - | **[[5oqd]] - DmPcG Phd2 and winged-helix domain <br /> | ||
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| - | *Polycomb SCM | ||
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| - | **[[2r57]] - DmPcG (mutant) <br /> | ||
| - | **[[2r58]], [[2r5a]] - DmPcG (mutant) + methyl-lysine<br /> | ||
| - | **[[2r5m]] - DmPcG (mutant) + peptide <br /> | ||
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| - | }} | ||
== References == | == References == | ||
Current revision
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3D structures of polycomb proteins
Polycomb complex proteins 3D structures
References
- ↑ Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C. A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. doi: 10.1016/j.celrep.2016.08.096. PMID:27705803 doi:http://dx.doi.org/10.1016/j.celrep.2016.08.096
- ↑ Poynter ST, Kadoch C. Polycomb and trithorax opposition in development and disease. Wiley Interdiscip Rev Dev Biol. 2016 Nov;5(6):659-688. doi: 10.1002/wdev.244., Epub 2016 Sep 1. PMID:27581385 doi:http://dx.doi.org/10.1002/wdev.244
