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4nso
From Proteopedia
(Difference between revisions)
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==Crystal structure of the effector-immunity protein complex== | ==Crystal structure of the effector-immunity protein complex== | ||
| - | <StructureSection load='4nso' size='340' side='right' caption='[[4nso]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='4nso' size='340' side='right'caption='[[4nso]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4nso]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4nso]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NSO FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nso OCA], [https://pdbe.org/4nso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nso RCSB], [https://www.ebi.ac.uk/pdbsum/4nso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nso ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VGRG3_VIBCH VGRG3_VIBCH] Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:23362380, PubMed:23341465). Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity (PubMed:23362380). Additionally, acts directly as an effector and targets the cell wall peptidoglycan layer of prey cells for degradation via its C-terminus (PubMed:23362380, PubMed:23341465). Toxicity is counteracted by a cognate immunity protein TsiV3 (PubMed:23362380, PubMed:24699653, PubMed:23341465).<ref>PMID:23341465</ref> <ref>PMID:23362380</ref> <ref>PMID:24699653</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Vibrio cholerae O1 biovar El Tor str. N16961]] |
| - | [[Category: | + | [[Category: Dong C]] |
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| - | + | ||
Current revision
Crystal structure of the effector-immunity protein complex
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