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1qym

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[[Image:1qym.gif|left|200px]]
 
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==X-ray structure of human gankyrin==
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The line below this paragraph, containing "STRUCTURE_1qym", creates the "Structure Box" on the page.
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<StructureSection load='1qym' size='340' side='right'caption='[[1qym]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qym]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QYM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qym OCA], [https://pdbe.org/1qym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qym RCSB], [https://www.ebi.ac.uk/pdbsum/1qym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qym ProSAT]</span></td></tr>
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{{STRUCTURE_1qym| PDB=1qym | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSD10_HUMAN PSD10_HUMAN] Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.<ref>PMID:10613832</ref> <ref>PMID:11900540</ref> <ref>PMID:11779854</ref> <ref>PMID:16023600</ref> <ref>PMID:18040287</ref> <ref>PMID:19490896</ref> <ref>PMID:19729910</ref> <ref>PMID:20628200</ref> Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.<ref>PMID:10613832</ref> <ref>PMID:11900540</ref> <ref>PMID:11779854</ref> <ref>PMID:16023600</ref> <ref>PMID:18040287</ref> <ref>PMID:19490896</ref> <ref>PMID:19729910</ref> <ref>PMID:20628200</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qy/1qym_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qym ConSurf].
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<div style="clear:both"></div>
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'''X-ray structure of human gankyrin'''
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==See Also==
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*[[Ankyrin 3D structures|Ankyrin 3D structures]]
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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==About this Structure==
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== References ==
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1QYM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYM OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma., Manjasetty BA, Quedenau C, Sievert V, Bussow K, Niesen F, Delbruck H, Heinemann U, Proteins. 2004 Apr 1;55(1):214-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14997555 14997555]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Buessow, K.]]
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[[Category: Buessow K]]
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[[Category: Delbrueck, H.]]
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[[Category: Delbrueck H]]
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[[Category: Heinemann, U.]]
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[[Category: Heinemann U]]
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[[Category: Manjasetty, B A.]]
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[[Category: Manjasetty BA]]
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[[Category: Niesen, F.]]
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[[Category: Niesen F]]
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[[Category: Quedenau, C.]]
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[[Category: Quedenau C]]
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[[Category: Sievert, V.]]
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[[Category: Sievert V]]
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[[Category: Ankyrin repeat]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:51:40 2008''
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Current revision

X-ray structure of human gankyrin

PDB ID 1qym

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