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1zro

From Proteopedia

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Current revision

Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose

Structural highlights

1zro is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.25Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q25735_PLAFA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Erythrocyte binding antigen 175 (EBA-175) is a P. falciparum protein that binds the major glycoprotein found on human erythrocytes, glycophorin A, during invasion. Here we present the crystal structure of the erythrocyte binding domain of EBA-175, RII, which has been established as a vaccine candidate. Binding sites for the heavily sialylated receptor glycophorin A are proposed based on a complex of RII with a glycan that contains the essential components required for binding. The dimeric organization of RII displays two prominent channels that contain four of the six observed glycan binding sites. Each monomer consists of two Duffy binding-like (DBL) domains (F1 and F2). F2 more prominently lines the channels and makes the majority of the glycan contacts, underscoring its role in cytoadherence and in antigenic variation in malaria. Our studies provide insight into the mechanism of erythrocyte invasion by the malaria parasite and aid in rational drug design and vaccines.

Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum.,Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L Cell. 2005 Jul 29;122(2):183-93. PMID:16051144^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L. Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum. Cell. 2005 Jul 29;122(2):183-93. PMID:16051144 doi:10.1016/j.cell.2005.05.033

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zro"

@@ Line 3: / Line 3: @@
 <StructureSection load='1zro' size='340' side='right'caption='[[1zro]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1zro]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZRO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1zro]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZRO FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zrl|1zrl]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zro OCA], [http://pdbe.org/1zro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zro RCSB], [http://www.ebi.ac.uk/pdbsum/1zro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zro ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zro OCA], [https://pdbe.org/1zro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zro RCSB], [https://www.ebi.ac.uk/pdbsum/1zro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zro ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q25735_PLAFA Q25735_PLAFA]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 35: / Line 37: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Plafa]]
+[[Category: Plasmodium falciparum]]
-[[Category: Enemark, E J]]
+[[Category: Enemark EJ]]
-[[Category: Joshua-Tor, L]]
+[[Category: Joshua-Tor L]]
-[[Category: Sim, B K]]
+[[Category: Sim BK]]
-[[Category: Tolia, N H]]
+[[Category: Tolia NH]]
-[[Category: Cell invasion]]
-[[Category: Dbl]]
-[[Category: Disease]]
-[[Category: Eba-175]]
-[[Category: Erythrocyte]]
-[[Category: Glycan]]
-[[Category: Glycophorin]]
-[[Category: Host]]
-[[Category: Invasion]]
-[[Category: Malaria]]
-[[Category: Rii]]
-[[Category: Sialic acid]]
-[[Category: Sialyllactose]]

1zro

From Proteopedia

Current revision

Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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