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1tr7

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==FimH adhesin receptor binding domain from uropathogenic E. coli==
==FimH adhesin receptor binding domain from uropathogenic E. coli==
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<StructureSection load='1tr7' size='340' side='right' caption='[[1tr7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='1tr7' size='340' side='right'caption='[[1tr7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1tr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TR7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1tr7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TR7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=DEG:BUTYL+ALPHA-D-MANNOPYRANOSIDE'>DEG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uwf|1uwf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=DEG:BUTYL+ALPHA-D-MANNOPYRANOSIDE'>DEG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tr7 OCA], [http://pdbe.org/1tr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tr7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tr7 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tr7 OCA], [https://pdbe.org/1tr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tr7 RCSB], [https://www.ebi.ac.uk/pdbsum/1tr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tr7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
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[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/1tr7_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/1tr7_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tr7 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Adhesin 3D structures|Adhesin 3D structures]]
*[[Urease|Urease]]
*[[Urease|Urease]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Berglund, J]]
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[[Category: Large Structures]]
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[[Category: Bouckaert, J]]
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[[Category: Berglund J]]
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[[Category: Choudhury, D]]
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[[Category: Bouckaert J]]
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[[Category: Cools, L]]
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[[Category: Choudhury D]]
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[[Category: Genst, E De]]
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[[Category: Cools L]]
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[[Category: Greve, H De]]
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[[Category: De Genst E]]
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[[Category: Hultgren, S J]]
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[[Category: De Greve H]]
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[[Category: Hung, C S]]
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[[Category: Hultgren SJ]]
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[[Category: Klemm, P]]
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[[Category: Hung CS]]
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[[Category: Knight, S D]]
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[[Category: Klemm P]]
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[[Category: Langermann, S]]
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[[Category: Knight SD]]
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[[Category: Oscarson, S]]
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[[Category: Langermann S]]
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[[Category: Pinkner, J]]
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[[Category: Oscarson S]]
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[[Category: Schembri, M]]
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[[Category: Pinkner J]]
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[[Category: Slattegard, R]]
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[[Category: Schembri M]]
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[[Category: Wuhrer, M]]
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[[Category: Slattegard R]]
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[[Category: Wyns, L]]
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[[Category: Wuhrer M]]
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[[Category: Zavialov, A]]
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[[Category: Wyns L]]
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[[Category: Adhesion]]
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[[Category: Zavialov A]]
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[[Category: Carbohydrate binding]]
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[[Category: Cell adhesion]]
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[[Category: Type-1 pili]]
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[[Category: Urinary tract infection]]
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[[Category: Uropathogenic e. coli]]
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Current revision

FimH adhesin receptor binding domain from uropathogenic E. coli

PDB ID 1tr7

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