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2zjd

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==Crystal Structure of LC3-p62 complex==
==Crystal Structure of LC3-p62 complex==
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<StructureSection load='2zjd' size='340' side='right' caption='[[2zjd]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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<StructureSection load='2zjd' size='340' side='right'caption='[[2zjd]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZJD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zjd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZJD FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zjd RCSB], [http://www.ebi.ac.uk/pdbsum/2zjd PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjd OCA], [https://pdbe.org/2zjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zjd RCSB], [https://www.ebi.ac.uk/pdbsum/2zjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MLP3B_HUMAN MLP3B_HUMAN]] Involved in formation of autophagosomal vacuoles (autophagosomes). [[http://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>
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[https://www.uniprot.org/uniprot/MLP3B_HUMAN MLP3B_HUMAN] Involved in formation of autophagosomal vacuoles (autophagosomes).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/2zjd_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/2zjd_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zjd ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2zjd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Microtubule-associated protein|Microtubule-associated protein]]
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*[[Microtubule-associated protein 3D structures|Microtubule-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ezaki, J]]
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[[Category: Large Structures]]
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[[Category: Ichimura, Y]]
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[[Category: Mus musculus]]
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[[Category: Komatsu, M]]
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[[Category: Ezaki J]]
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[[Category: Kominami, E]]
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[[Category: Ichimura Y]]
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[[Category: Kumanomidou, T]]
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[[Category: Komatsu M]]
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[[Category: Mizushima, T]]
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[[Category: Kominami E]]
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[[Category: Sou, Y]]
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[[Category: Kumanomidou T]]
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[[Category: Tanaka, K]]
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[[Category: Mizushima T]]
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[[Category: Ueno, T]]
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[[Category: Sou Y]]
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[[Category: Yamane, T]]
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[[Category: Tanaka K]]
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[[Category: Apoptosis]]
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[[Category: Ueno T]]
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[[Category: Apoptosis inhibitor-apoptosis complex]]
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[[Category: Yamane T]]
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[[Category: Autophagy]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Differentiation]]
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[[Category: Endosome]]
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[[Category: Immune response]]
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[[Category: Lc3]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Microtubule-associated protein 1 light chain 3]]
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[[Category: Nucleus]]
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[[Category: P62]]
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[[Category: Phosphoprotein]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc-finger]]
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Current revision

Crystal Structure of LC3-p62 complex

PDB ID 2zjd

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