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7un6

From Proteopedia

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'''Unreleased structure'''
 
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The entry 7un6 is ON HOLD
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==Complex of UBE2O with NAP1L1==
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<StructureSection load='7un6' size='340' side='right'caption='[[7un6]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7un6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UN6 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7un6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7un6 OCA], [https://pdbe.org/7un6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7un6 RCSB], [https://www.ebi.ac.uk/pdbsum/7un6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7un6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBE2O_HUMAN UBE2O_HUMAN] E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).<ref>PMID:23381138</ref> <ref>PMID:23452853</ref> <ref>PMID:23455153</ref> <ref>PMID:24703950</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Sedor SF]]
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[[Category: Shao S]]
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[[Category: Yip MCJ]]

Current revision

Complex of UBE2O with NAP1L1

PDB ID 7un6

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