This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5u1m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5u1m" [edit=sysop:move=sysop])
Current revision (15:44, 6 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5u1m is ON HOLD
+
==Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor==
-
 
+
<StructureSection load='5u1m' size='340' side='right'caption='[[5u1m]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
Authors: Eck, M.J., Dhe-Paganon, S.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5u1m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U1M FirstGlance]. <br>
-
Description: Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-
[[Category: Eck, M.J]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u1m OCA], [https://pdbe.org/5u1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u1m RCSB], [https://www.ebi.ac.uk/pdbsum/5u1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u1m ProSAT]</span></td></tr>
-
[[Category: Dhe-Paganon, S]]
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[https://omim.org/entry/125853 125853].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref> <ref>PMID:14707024</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Dhe-Paganon S]]
 +
[[Category: Eck MJ]]

Current revision

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

PDB ID 5u1m

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5u1m"
Personal tools