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3akk
From Proteopedia
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| - | [[Image:3akk.png|left|200px]] | ||
| - | + | ==Crystal structure of A Helicobacter pylori proinflammatory kinase CtkA== | |
| - | + | <StructureSection load='3akk' size='340' side='right'caption='[[3akk]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3akk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_J99 Helicobacter pylori J99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AKK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3akk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3akk OCA], [https://pdbe.org/3akk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3akk RCSB], [https://www.ebi.ac.uk/pdbsum/3akk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3akk ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/CTKA_HELPJ CTKA_HELPJ] Virulence factor acting as a pro-inflammatory protein that induces the secretion of the pro-inflammatory cytokines TNF-alpha (tumor necrosis factor-alpha) and IL-8 (interleukin-8) from human macrophages, as well as enhanced translocation of the transcription factor NF-kappa-B complex in macrophages. Is a kinase capable of autophosphorylating itself at a threonine residue near the N-terminus. Also leads to enhanced phosphorylation of the NF-kappa-B p65 subunit (RELA) at 'Ser-276' in human epithelial cancer cells; its kinase activity is required for this enhanced phosphorylation that up-regulates NF-kappa-B activity, but it does not directly phosphorylate this protein. Thus, the kinase activity of CtkA may play an important role in the induction of host inflammatory responses during H.pylori infection.<ref>PMID:17993522</ref> <ref>PMID:21098302</ref> | |
| - | + | == References == | |
| - | < | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Helicobacter pylori J99]] | |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Kim DJ]] | |
| - | == | + | [[Category: Suh SW]] |
| - | [[3akk]] is a 4 chain structure with sequence from [ | + | |
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| - | == | + | |
| - | < | + | |
| - | [[Category: Helicobacter pylori]] | + | |
| - | [[Category: | + | |
| - | [[Category: Kim | + | |
| - | [[Category: Suh | + | |
Current revision
Crystal structure of A Helicobacter pylori proinflammatory kinase CtkA
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