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3un4

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[[Image:3un4.png|left|200px]]
 
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==Yeast 20S proteasome in complex with PR-957 (morpholine)==
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The line below this paragraph, containing "STRUCTURE_3un4", creates the "Structure Box" on the page.
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<StructureSection load='3un4' size='340' side='right'caption='[[3un4]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3un4]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UN4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=04C:1,2,4-TRIDEOXY-4-METHYL-2-{[N-(MORPHOLIN-4-YLACETYL)-L-ALANYL-O-METHYL-L-TYROSYL]AMINO}-1-PHENYL-D-XYLITOL'>04C</scene></td></tr>
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{{STRUCTURE_3un4| PDB=3un4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3un4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3un4 OCA], [https://pdbe.org/3un4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3un4 RCSB], [https://www.ebi.ac.uk/pdbsum/3un4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3un4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
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===Yeast 20S proteasome in complex with PR-957 (morpholine)===
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_22341445}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22341445 is the PubMed ID number.
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Basler M]]
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{{ABSTRACT_PUBMED_22341445}}
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[[Category: Groettrup M]]
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[[Category: Groll M]]
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==About this Structure==
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[[Category: Heinemeyer W]]
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[[3un4]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UN4 OCA].
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[[Category: Huber E]]
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[[Category: Kirk C]]
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==Reference==
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[[Category: Schwab R]]
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<ref group="xtra">PMID:022341445</ref><references group="xtra"/>
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Basler, M.]]
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[[Category: Groettrup, M.]]
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[[Category: Groll, M.]]
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[[Category: Heinemeyer, W.]]
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[[Category: Huber, E.]]
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[[Category: Kirk, C.]]
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[[Category: Schwab, R.]]
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[[Category: Antigen presentation]]
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[[Category: Drug development]]
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[[Category: Hydrolase -hydrolase-inhibitor complex]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Proteasome]]
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[[Category: Protein degradation]]
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Current revision

Yeast 20S proteasome in complex with PR-957 (morpholine)

PDB ID 3un4

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