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3un4
From Proteopedia
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| - | [[Image:3un4.png|left|200px]] | ||
| - | + | ==Yeast 20S proteasome in complex with PR-957 (morpholine)== | |
| - | + | <StructureSection load='3un4' size='340' side='right'caption='[[3un4]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3un4]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UN4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=04C:1,2,4-TRIDEOXY-4-METHYL-2-{[N-(MORPHOLIN-4-YLACETYL)-L-ALANYL-O-METHYL-L-TYROSYL]AMINO}-1-PHENYL-D-XYLITOL'>04C</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3un4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3un4 OCA], [https://pdbe.org/3un4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3un4 RCSB], [https://www.ebi.ac.uk/pdbsum/3un4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3un4 ProSAT]</span></td></tr> |
| - | [[3un4]] is a | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | ||
==See Also== | ==See Also== | ||
| - | *[[Proteasome|Proteasome]] | + | *[[Proteasome 3D structures|Proteasome 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | [[Category: Saccharomyces cerevisiae]] | + | [[Category: Basler M]] |
| - | [[Category: Basler | + | [[Category: Groettrup M]] |
| - | [[Category: Groettrup | + | [[Category: Groll M]] |
| - | [[Category: Groll | + | [[Category: Heinemeyer W]] |
| - | [[Category: Heinemeyer | + | [[Category: Huber E]] |
| - | [[Category: Huber | + | [[Category: Kirk C]] |
| - | [[Category: Kirk | + | [[Category: Schwab R]] |
| - | [[Category: Schwab | + | |
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Current revision
Yeast 20S proteasome in complex with PR-957 (morpholine)
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