4gk7
From Proteopedia
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| - | [[Image:4gk7.png|left|200px]] | ||
| - | + | ==yeast 20S proteasome in complex with the Syringolin-Glidobactin chimera== | |
| + | <StructureSection load='4gk7' size='340' side='right'caption='[[4gk7]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gk7]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GK7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JT:(4R)-4-AMINO-5-METHYLHEXANOIC+ACID'>0JT</scene>, <scene name='pdbligand=LYH:3,4+ENE-LYSINE'>LYH</scene>, <scene name='pdbligand=MH9:(2E,4E)-DODECA-2,4-DIENOIC+ACID'>MH9</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gk7 OCA], [https://pdbe.org/4gk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gk7 RCSB], [https://www.ebi.ac.uk/pdbsum/4gk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gk7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | ||
| - | == | + | ==See Also== |
| - | + | *[[Proteasome 3D structures|Proteasome 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[ | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | + | [[Category: Synthetic construct]] | |
| - | + | [[Category: Bachmann A]] | |
| - | < | + | [[Category: Groll M]] |
| - | [[Category: | + | [[Category: Stein ML]] |
| - | [[Category: Saccharomyces cerevisiae]] | + | |
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Current revision
yeast 20S proteasome in complex with the Syringolin-Glidobactin chimera
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