This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3rv8
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_3rv8| PDB=3rv8 | SCENE= }} | ||
| - | ===Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group=== | ||
| - | {{ABSTRACT_PUBMED_22607697}} | ||
| - | == | + | ==Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group== |
| - | [[http://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU | + | <StructureSection load='3rv8' size='340' side='right'caption='[[3rv8]], [[Resolution|resolution]] 2.29Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3rv8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RV8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RVC:3-{[(Z)-1-CARBOXY-2-CYCLOPROPYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>RVC</scene>, <scene name='pdbligand=VCE:3-{[(E)-1-CARBOXY-2-CYCLOPROPYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>VCE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rv8 OCA], [https://pdbe.org/3rv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rv8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rv8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Isochorismate pyruvate lyase|Isochorismate pyruvate lyase]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: Bulloch | + | [[Category: Bulloch EMM]] |
| - | [[Category: Chi | + | [[Category: Chi G]] |
| - | [[Category: Lott | + | [[Category: Lott JS]] |
| - | [[Category: Manos-Turvey | + | [[Category: Manos-Turvey A]] |
| - | [[Category: Payne | + | [[Category: Payne RJ]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group
| |||||||||||
